Dynamic Changes in Cerebral Oxygenation and Arterial Pressure During Repeated Rapid Hypotension.

Saya Tokuda, Hyuga Kojima, Hiroki Baba, Hajime Tamiya, Atsuhiro Tsubaki

Abstract read

In one paragraph

Article in Advances in experimental medicine and biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Saya TokudaDepartment of Physical Therapy, Faculty of Rehabilitation, Niigata University of Health and Welfare, Niigata, Japan.

Hyuga KojimaDepartment of Physical Therapy, Faculty of Rehabilitation, Niigata University of Health and Welfare, Niigata, Japan.

Hiroki BabaDepartment of Physical Therapy, Faculty of Rehabilitation, Niigata University of Health and Welfare, Niigata, Japan.

Hajime TamiyaDepartment of Physical Therapy, Faculty of Rehabilitation, Niigata University of Health and Welfare, Niigata, Japan.

Atsuhiro TsubakiDepartment of Physical Therapy, Faculty of Rehabilitation, Niigata University of Health and Welfare, Niigata, Japan. tsubaki@nuhw.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to determine the changes in the time to nadir of mean arterial pressure (MAP) and oxygenated hemoglobin (O₂Hb) in the right and left prefrontal cortices (R-PFC and L-PFC, respectively) during repeated episodes of rapid hypotension. Four cycles of blood pressure reduction were induced via bilateral thigh occlusion at 250 mmHg followed by rapid deflation. Sixteen healthy male university students participated. MAP was recorded beat by beat, and O₂Hb was continuously monitored using near-infrared spectroscopy. The time from deflation to nadir was measured and compared across each deflation cycle. MAP and O₂Hb in the R-PFC and L-PFC reached their nadir values approximately 7 to 8 s post-deflation, with no significant changes observed across repetitions. These findings indicate that the time to nadir of MAP and O₂Hb in the R-PFC and L-PFC remains stable during repeated rapid hypotension.

Indexed as

Arterial PressureCerebrovascular CirculationHypotensionOxygenPrefrontal CortexAdultHumansMaleOxygen SaturationOxyhemoglobinsSpectroscopy, Near-InfraredYoung AdultOxygenOxyhemoglobinsAcute hypotensionMean arterial pressureNear-infrared spectroscopyOxygenated hemoglobinPrefrontal cortex

Identifiers

PMID41577925

DOI10.1007/s00421-019-04101-0

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.