Net Water Uptake and Cerebral Microcirculation in Perilesional Penumbra in TBI: CT Perfusion Study.

Alex O Trofimov, Ilya Kochsheev, George Kalentyev, Ekaterina Volkova, Edwin M Nemoto, Olga Bragina, Denis E Bragin

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Article in Advances in experimental medicine and biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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7 authors.

Alex O TrofimovDepartment of Neurological Diseases, Privolzhsky Research Medical University, Nizhny Novgorod, Russia.

Ilya KochsheevDepartment of Neurological Diseases, Privolzhsky Research Medical University, Nizhny Novgorod, Russia.

George KalentyevDepartment of Neurological Diseases, Privolzhsky Research Medical University, Nizhny Novgorod, Russia.

Ekaterina VolkovaDepartment of Neurological Diseases, Privolzhsky Research Medical University, Nizhny Novgorod, Russia.

Edwin M NemotoDepartment of Neurology, University of New Mexico School of Medicine, Albuquerque, NM, USA.

Olga BraginaLovelace Biomedical Research Institute, Albuquerque, NM, USA.

Denis E BraginDepartment of Neurology, University of New Mexico School of Medicine, Albuquerque, NM, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of our study was to compare brain tissue net water uptake (NWU), cerebral oxygenation, and microcirculation changes in perilesional penumbra foci (PPF) in moderate isolated traumatic brain injury (moiTBI) patients. MATERIALS AND

methods77 moiTBI patients (women 35; men 42, age 37 years [34;39]) with unilateral frontal/frontotemporal lesions (Marshall II-III) were included in this retrospective, non-randomized, single-center study. Perfusion parameters were measured in PPF zones and determined using multiphase perfusion computed tomography (PCT) in the first 2 days after trauma and admission. NWU in hypoattenuated perilesional zones was calculated using non-contrast CT. Cerebral oxygenation (SctO

resultsIn PPF, SctO

conclusionsBrain edema in PPF was significantly associated with cerebral microcirculation and cerebral O

Indexed as

BrainBrain Injuries, TraumaticCerebrovascular CirculationMicrocirculationTomography, X-Ray ComputedWaterAdultFemaleHumansMaleMiddle AgedOxygenPerfusion ImagingRetrospective StudiesOxygenWaterCerebral oxygenationNet water uptakePerfusion CTPerilesional penumbra

Identifiers

PMID41577923

DOI10.1136/tsaco-2024-001501

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.