ArticleAdvances in experimental medicine and biology2026
Unlocking Unique Physiological Reactions: Novel Insights into Four Cerebral and Systemic Physiological Responses to Colored Light.
Article in Advances in experimental medicine and biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundFor several years, our research group has been systematically investigating how changes in cerebral hemodynamics as well as systemic physiology can be induced by colored light exposure (CLE). We have observed that these physiological changes can differ between subjects for exactly the same CLE stimulus. In the present case series, we report specific physiological reactivity patterns from four subjects.
methodsA total of 36 subjects participated in the study. These subjects were exposed to blue and red light while performing a 2-back task. For the present analysis, we selected four subjects as representative examples of distinct response patterns. We simultaneously measured changes in cerebral and systemic physiological parameters using the systemic physiology augmented functional near-infrared spectroscopy (SPA-fNIRS) method. The SPA-fNIRS method included oxygenated hemoglobin ([O
resultsWe identified four distinct patterns of physiological responses. Pattern 1: For all parameters except MAP, the subject's response to blue and red light remained consistent. Pattern 2: Similar to the previous case, there was no significant contrast between red and blue with respect to changes in cerebral hemodynamics. Similar patterns were also detected for P
conclusionsIn our analysis of SPA-fNIRS measurements, we identified four subjects with specific physiological reactivity patterns to a combined CLE and cognitive task. Individual physiological reactivity or physiological constitution should be taken into account when analyzing physiological data on CLE to enable a more adequate interpretation of the results.
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