Evidence map›Paper›PMID 41577912›Full record

ArticleAdvances in experimental medicine and biology2026

The Role of Nitric Oxide in Regulating Microvascular Oxygen Pressure During Diaphragm Contraction in Rats.

Kazuki Hotta, Narumi Fukuzaki, Rin Kataoka, Kota Izawa, Shuri Arai, Kentaro Kamiya, Atsuhiko Matsunaga

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Article in Advances in experimental medicine and biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kazuki HottaDepartment of Rehabilitation, School of Allied Health Sciences, Kitasato University, Sagamihara, Japan. hotta.kazuki@kitasato-u.ac.jp.
Narumi FukuzakiDepartment of Rehabilitation Sciences, Graduate School of Medical Sciences, Kitasato University, Sagamihara, Japan.
Rin KataokaDepartment of Rehabilitation Sciences, Graduate School of Medical Sciences, Kitasato University, Sagamihara, Japan.
Kota IzawaDepartment of Rehabilitation Sciences, Graduate School of Medical Sciences, Kitasato University, Sagamihara, Japan.
Shuri AraiDepartment of Rehabilitation Sciences, Graduate School of Medical Sciences, Kitasato University, Sagamihara, Japan.
Kentaro KamiyaDepartment of Rehabilitation, School of Allied Health Sciences, Kitasato University, Sagamihara, Japan.
Atsuhiko MatsunagaDepartment of Rehabilitation, School of Allied Health Sciences, Kitasato University, Sagamihara, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe diaphragm muscle is the primary muscle involved in inspiration and is unique to mammals. Because the diaphragm is a constantly active muscle, its contraction may depend on oxidative phosphorylation and O

methodsWistar male rats (n = 6, 10 wks old, 311 ± 14 g) were mechanically ventilated under isoflurane anesthesia. The diaphragm was exposed to measure microvascular partial O DISCUSSION: The time constant in PO

conclusionThe NO has a crucial role in the diaphragm oxygen dynamics of intact rats.

Indexed as

DiaphragmMicrovesselsMuscle ContractionNitric OxideOxygenAnimalsEnzyme InhibitorsMaleNG-Nitroarginine Methyl EsterNitric Oxide Synthase Type IIIRatsRats, WistarEnzyme InhibitorsNG-Nitroarginine Methyl EsterNitric OxideNitric Oxide Synthase Type IIINos3 protein, ratOxygenCapillaryeNOSL-NAMEMicrovascular oxygen pressureRespiratory muscle

Identifiers

PMID41577912

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.