Evidence map›Paper›PMID 41577908›Full record

ArticleAdvances in experimental medicine and biology2026

Role of the Dual-Specificity Phosphatase 6 (DUSP6) in the Activation of ERK1/2 Signaling by Hypoxia or Acidosis in Tumor Cells.

Anne Riemann, Sarah Reime, Oliver Thews

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Article in Advances in experimental medicine and biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Anne RiemannJulius-Bernstein-Institute of Physiology, University of Halle, Halle, Germany.
Sarah ReimeJulius-Bernstein-Institute of Physiology, University of Halle, Halle, Germany.
Oliver ThewsJulius-Bernstein-Institute of Physiology, University of Halle, Halle, Germany. oliver.thews@medizin.uni-halle.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Important pathophysiological characteristics of human tumors are the presence of hypoxia and of an extracellular acidosis. Both metabolic parameters can affect the malignant behavior of tumors but also the response to treatments. Here the modulation of the ERK1/2 signaling plays a relevant role. ERK1/2 activation is controlled by the dual-specificity phosphatase 6 (Dusp6) and by this modulates cellular processes. For this reason, the study analyzed the impact of hypoxia and/or extracellular acidosis on the expression of Dusp6. Several tumor cell lines were exposed to control conditions (room air, pH = 7.4), hypoxia (pO

Indexed as

AcidosisDual Specificity Phosphatase 6MAP Kinase Signaling SystemMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3NeoplasmsCell HypoxiaCell Line, TumorGene Expression Regulation, NeoplasticHumansTOR Serine-Threonine KinasesDual Specificity Phosphatase 6DUSP6 protein, humanMAPK3 protein, humanMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3MTOR protein, humanTOR Serine-Threonine KinasesCell signalingEts2 expressionmTORp53 expressionTumor acidosis

Identifiers

PMID41577908

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.