Evidence map›Paper›PMID 41577822›Full record

SynthesisCellular and molecular neurobiology2026

Association between Gastroesophageal Reflux and Sleep Disorder: A Systematic Review and Meta-analysis.

Chao Ren, Jun-Jie Zou, Zhen Wang, Jia-Jia Yun, Ya-Lei Li, Yu Yang, Ze-Jiong Li, Meng-Yuan Shen

Abstract readMeta-AnalysisSystematic ReviewReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Cellular and molecular neurobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chao Ren *Department of Neurology, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China. renchaotg@126.com.
Jun-Jie Zou *Department of Neurology, Yantai Penglai People's Hospital, Yantai, 264117, China.
Zhen Wang *Rehabilitation Center, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, China.
Jia-Jia YunSpecial Education and Rehabilitation College, Binzhou Medical University, Yantai, 264000, China.
Ya-Lei LiSpecial Education and Rehabilitation College, Binzhou Medical University, Yantai, 264000, China.
Yu YangSpecial Education and Rehabilitation College, Binzhou Medical University, Yantai, 264000, China.
Ze-Jiong LiThe First Affiliated Hospital of Zhejiang Chinese Medical University, Zhejiang Provincial Hospital of Traditional Chinese Medicine), Zhejiang, 310053, China. zejiong-li@zcmu.edu.cn.
Meng-Yuan ShenThe First Affiliated Hospital of Zhejiang Chinese Medical University, Zhejiang Provincial Hospital of Traditional Chinese Medicine), Zhejiang, 310053, China. mengyuan-shen@zcmu.edu.cn.

Funding

the Taishan Scholar Project (NO. tsqn202312392)
6 · The paper itself

Abstract

An association between gastroesophageal reflux disease (GERD) and sleep disorder has been reported. However, the magnitude of this association remains poorly understood. Therefore, we aimed to systematically evaluate this relationship. We conducted a comprehensive search for observational studies in eight databases from their inception to February 28, 2025. The characteristics of each study and pooled risk ratio (RR) with corresponding confidence intervals were calculated. Subgroup analyses were performed to explore sources of heterogeneity. A total of eighteen studies involving 110,417 participants met the inclusion criteria and were included in this meta-analysis. Our findings indicate a statistically significant unidirectional association between GERD and sleep disorder (RR = 2.02, 95% CI 1.71 to 2.37). Subgroup analyses consistently demonstrated an association between sleep disorder and GERD regardless of the diagnostic tools used for either condition (P = 0.32 for GERD diagnosis tools and P = 0.80 for sleep disorder diagnosis tools). Sensitivity analysis indicates that the conclusions are highly stable, and GRADEpro evaluation results have a low level of evidence. This meta-analysis reveals a significant correlation between sleep disorder and GERD. More studies under consistent conditions are needed to validate these findings.

Indexed as

Gastroesophageal RefluxSleep Wake DisordersHumansGastroesophageal reflux diseaseMeta-analysisSleep disorderSystematic review

Identifiers

PMID41577822
PMCPMC12891279

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.