Evidence map›Paper›PMID 41577662›Full record

ArticleNature communications2026

The E3 ligases Itch and WWP2 regulate autoimmune neuroinflammation by controlling T

Mei Zhao, Chao Zhang, Xin Zhang, Qingdian Mu, Qian Li, Yun-Cai Liu

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mei ZhaoInstitute for Immunology and School of Basic Medical Science, Tsinghua University, Beijing, China. zhaom18@tsinghua.org.cn.ORCID http://orcid.org/0009-0005-1917-8129
Chao ZhangInstitute for Immunology and School of Basic Medical Science, Tsinghua University, Beijing, China.
Xin ZhangInstitute for Immunology and School of Basic Medical Science, Tsinghua University, Beijing, China.
Qingdian MuInstitute for Immunology and School of Basic Medical Science, Tsinghua University, Beijing, China.
Qian LiInstitute for Immunology and School of Basic Medical Science, Tsinghua University, Beijing, China.
Yun-Cai LiuInstitute for Immunology and School of Basic Medical Science, Tsinghua University, Beijing, China. yuncai_liu@mail.tsinghua.edu.cn.ORCID http://orcid.org/0000-0002-0996-7109

Funding

Ministry of Science and Technology of the People's Republic of China (Chinese Ministry of Science and Technology) YFC2300503
6 · The paper itself

Abstract

Multiple sclerosis (MS) is a neurodegenerative autoimmune disease primarily mediated by T helper 17 (T

Indexed as

Encephalomyelitis, Autoimmune, ExperimentalInterleukin-4Repressor ProteinsSTAT5 Transcription FactorTh17 CellsTh2 CellsUbiquitin-Protein LigasesAnimalsCell DifferentiationDermatitis, AtopicFemaleHumansJanus Kinase 3MiceMice, Inbred C57BLMice, KnockoutIl4 protein, mouseInterleukin-4Itch protein, mouseJak3 protein, mouseJanus Kinase 3Repressor ProteinsSTAT5 Transcription FactorUbiquitin-Protein Ligases

Identifiers

PMID41577662
PMCPMC12848126

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.