Salutogenomics: embracing the full spectrum of human health.

Noah Collins, Grace Heyborne, Agustín Fuentes, Justin Lund, Melissa Ilardo

Abstract readReview

In one paragraph

Review in Trends in genetics : TIG, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Noah CollinsDepartment of Anthropology, Princeton University, Princeton, NJ, USA.

Grace HeyborneDepartment of Biomedical Informatics, University of Utah, Salt Lake City, UT, USA.

Agustín FuentesDepartment of Anthropology, Princeton University, Princeton, NJ, USA.

Justin LundDepartment of Anatomy and Cell Biology, Oklahoma State University Center for Health Sciences, Tulsa, OK, USA; Division of Anthropology, California State University, Fullerton, Fullerton, CA, USA. Electronic address: JLund@fullerton.edu.

Melissa IlardoDepartment of Biomedical Informatics, University of Utah, Salt Lake City, UT, USA; Department of Human Genetics, University of Utah, Salt Lake City, UT, USA. Electronic address: melissa.ilardo@utah.edu.

Funding

UNIVERSITY OF UTAH MEDICAL INFORMATICS TRAININGT15LM007124 · NLM · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Karen Louise Eilbeck · 1997 to 2026

$22.0M

NLM NIH HHS T15 LM007124

6 · The paper itself

Abstract

Modern biomedical genomics has principally centered on disease, leveraging genomic insights to identify disease-associated genotypes. While valuable, this approach is overly reliant on a positivist, disease-centric perspective that often goes hand-in-hand with patterns like deficit framing, racialized medical stereotyping, and genetic determinism. These practices and their underlying beliefs are detrimental for patients, who experience worse health outcomes as a result, and for participant communities, who endure associated stigmas. This commentary seeks to examine the consequences of this narrow lens and to describe the benefits of an alternative approach: salutogenomics, which highlights the full spectrum of human health. Additionally, we explore how adopting diverse knowledge production paradigms could refashion Western genomic methodologies.

Indexed as

Genetics, MedicalGenomicsHumansdiseaseethicsgenetic resiliencehealth equityhuman genomicsmedical genetics

Identifiers

PMID41577507

DOI10.1016/j.tig.2025.12.004

PMCPMC13193198

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.