Evidence map›Paper›PMID 41577339›Full record

ArticleJournal of chemical information and modeling2026

HelixSide: A Comprehensive Method for Local and Global Orientational Analysis of Proteins.

Sakari Pirnes, Veera Hägg, Mykhailo Girych, Ilpo Vattulainen, Giray Enkavi

Abstract read
In one paragraph

Article in Journal of chemical information and modeling, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sakari PirnesDepartment of Mathematics and Statistics, University of Helsinki, Helsinki 00014, Finland.ORCID 0000-0002-2427-1134
Veera HäggDepartment of Physics, University of Helsinki, Helsinki 00014, Finland.ORCID 0009-0000-3350-7295
Mykhailo GirychDepartment of Physics, University of Helsinki, Helsinki 00014, Finland.
Ilpo VattulainenDepartment of Physics, University of Helsinki, Helsinki 00014, Finland.ORCID 0000-0001-7408-3214
Giray EnkaviDepartment of Physics, University of Helsinki, Helsinki 00014, Finland.ORCID 0000-0001-5033-8649

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Understanding the relative orientation of protein secondary structure elements is crucial for elucidating their tertiary organization, function, and interactions. Here, we introduce HelixSide, a comprehensive method for systematically quantifying geometrical metrics of helical secondary structures, including widely used measures, such as tilt and kink angles. Additionally, to characterize the orientation of secondary structure motifs relative to each other or to the helical axis, we introduce a new quantity, the

Indexed as

ProteinsReceptor, InsulinGlycophorinsMolecular Dynamics SimulationProtein Structure, SecondaryGlycophorinsProteinsReceptor, Insulin

Identifiers

PMID41577339
PMCPMC12892334

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.