Evidence map›Paper›PMID 41576945›Full record

ArticleCell genomics2026

Uncovering the signatures of aging and senescence in the human dorsolateral prefrontal cortex.

Nicholas X Sloan, Jason Mares, Aidan C Daly, Shaunice Grier, Imdadul Haq, Christopher A Jackson, Natalie Barretto, Obadele Casel, Kristy Kang, Shruti Khiste and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. The Sixth Annual Symposium of the Midwest Aging Consortium.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026
    Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

26 authors.

Nicholas X SloanDepartment of Neurology, Columbia Irving Medical Center, New York, NY, USA; Motor Neuron Center, Columbia University, New York, NY, USA; Center for Genomics of Neurodegenerative Disease, New York Genome Center, New York, NY, USA.
Jason MaresDepartment of Neurology, Columbia Irving Medical Center, New York, NY, USA; Center for Translational and Computational Neuroimmunology, Columbia Irving Medical Center, New York, NY, USA.
Aidan C DalyCenter for Genomics of Neurodegenerative Disease, New York Genome Center, New York, NY, USA.
Shaunice GrierDepartment of Neurology, Columbia Irving Medical Center, New York, NY, USA; Motor Neuron Center, Columbia University, New York, NY, USA; Center for Genomics of Neurodegenerative Disease, New York Genome Center, New York, NY, USA.
Imdadul HaqDepartment of Neurology, Columbia Irving Medical Center, New York, NY, USA; Motor Neuron Center, Columbia University, New York, NY, USA; Center for Genomics of Neurodegenerative Disease, New York Genome Center, New York, NY, USA.
Christopher A JacksonCenter for Genomics of Neurodegenerative Disease, New York Genome Center, New York, NY, USA.
Natalie BarrettoDepartment of Neurology, Columbia Irving Medical Center, New York, NY, USA; Motor Neuron Center, Columbia University, New York, NY, USA; Center for Genomics of Neurodegenerative Disease, New York Genome Center, New York, NY, USA.
Obadele CaselCenter for Genomics of Neurodegenerative Disease, New York Genome Center, New York, NY, USA.
Kristy KangCenter for Genomics of Neurodegenerative Disease, New York Genome Center, New York, NY, USA.
Shruti KhisteCenter for Genomics of Neurodegenerative Disease, New York Genome Center, New York, NY, USA.
Kennedy HarrisDepartment of Neurology, Columbia Irving Medical Center, New York, NY, USA; Motor Neuron Center, Columbia University, New York, NY, USA; Center for Genomics of Neurodegenerative Disease, New York Genome Center, New York, NY, USA.
Jacqueline EschbachDepartment of Neurology, Columbia Irving Medical Center, New York, NY, USA; Motor Neuron Center, Columbia University, New York, NY, USA; Center for Genomics of Neurodegenerative Disease, New York Genome Center, New York, NY, USA; Center for Translational and Computational Neuroimmunology, Columbia Irving Medical Center, New York, NY, USA.
Benjamin T FullertonDepartment of Neurology, Columbia Irving Medical Center, New York, NY, USA; Motor Neuron Center, Columbia University, New York, NY, USA; Center for Genomics of Neurodegenerative Disease, New York Genome Center, New York, NY, USA.
Courteney MattisonDepartment of Neurology, Columbia Irving Medical Center, New York, NY, USA; Center for Translational and Computational Neuroimmunology, Columbia Irving Medical Center, New York, NY, USA.
Brhan GebremedhinCenter for Genomics of Neurodegenerative Disease, New York Genome Center, New York, NY, USA.
Joana PetrescuDepartment of Neurology, Columbia Irving Medical Center, New York, NY, USA; Motor Neuron Center, Columbia University, New York, NY, USA; Center for Genomics of Neurodegenerative Disease, New York Genome Center, New York, NY, USA.
Lilian CoieCenter for Genomics of Neurodegenerative Disease, New York Genome Center, New York, NY, USA.
Maria Hauge PedersenCenter for Genomics of Neurodegenerative Disease, New York Genome Center, New York, NY, USA.
Ke ZhangCutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Boston, MA, USA.
Jian ShuCutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Boston, MA, USA; Harvard-MIT Program in Health Sciences and Technology, MIT, Cambridge, MA, USA.
Andrew F TeichDepartment of Neurology, Columbia Irving Medical Center, New York, NY, USA; Department of Pathology and Cell Biology, Columbia University, New York, NY, USA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.
Hasini ReddyDepartment of Pathology and Cell Biology, Columbia University, New York, NY, USA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.
Colin P SmithCentre for Clinical Brain Sciences, The University of Edinburgh, EH16 4SB Edinburgh, UK.
Yousin SuhDepartment of Obstetrics and Gynecology, Columbia University, New York, NY, USA; Department of Genetics and Development, Columbia University, New York, NY, USA.
Vilas MenonDepartment of Neurology, Columbia Irving Medical Center, New York, NY, USA; Center for Translational and Computational Neuroimmunology, Columbia Irving Medical Center, New York, NY, USA. Electronic address: vm2545@cumc.columbia.edu.
Hemali PhatnaniDepartment of Neurology, Columbia Irving Medical Center, New York, NY, USA; Motor Neuron Center, Columbia University, New York, NY, USA; Center for Genomics of Neurodegenerative Disease, New York Genome Center, New York, NY, USA. Electronic address: hp2286@cumc.columbia.edu.

Funding

Research Education CoreP30AG066462 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PHILIP L DE JAGER · 2020 to 2026
$30.1M
Data Analysis CoreU54AG076040 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PHATNANI, HEMALI · 2021 to 2025
$13.1M
NIA NIH HHS P30 AG066462NIA NIH HHS U54 AG076040
6 · The paper itself

Abstract

We performed Visium spatial transcriptomics (ST) and single-nucleus RNA sequencing (snRNA-seq) on a cohort of nonpathological human tissues to uncover signatures of aging and senescence in the dorsolateral prefrontal cortex (dlPFC). In doing so, we identified gene expression changes characteristic of aged cortical layers. The cellular composition of the dlPFC also changed with age, with increased homeostatic astrocyte abundance and with decreased somatostatin (SST) inhibitory neurons. Nuclei from dlPFC cell types displayed a strong decline in oxidative phosphorylation- and cytoplasmic translation-related genes with age. Additionally, oligodendrocytes showed several hallmarks of senescence and a linear increase in CDKN2A expression with age. Combined analysis of ST and snRNA-seq datasets revealed astrocyte- and vascular cell-related gene expression programs in the white matter and layer 1 that were strongly enriched with age and for senescence-associated genes. These findings will help facilitate future studies exploring the role of senescent cell subpopulations in the aging brain.

Indexed as

AgingCellular SenescenceDorsolateral Prefrontal CortexPrefrontal CortexAdultAgedAged, 80 and overAstrocytesFemaleHumansMaleMiddle AgedNeuronsOligodendrogliaSpatial TranscriptomicsTranscriptomeagingprefrontal cortexsenescencesingle-nucleus transcriptomicsspatial transcriptomicstranscriptome

Identifiers

PMID41576945
PMCPMC12903411

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.