Evidence map›Paper›PMID 41576711›Full record

ReviewPsychoneuroendocrinology2026

Considerations and practical recommendations for identifying perimenopause in longitudinal research.

Megan E Huibregtse, Linzie Taylor, Trinidi Prochaska, Amanda R Arnold, C Neill Epperson, E Britton Chahine, Alicia K Smith, Abigail Powers, Vasiliki Michopoulos, Jennifer S Stevens

Abstract readReview
In one paragraph

Review in Psychoneuroendocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Megan E HuibregtseDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, United States; Department of Health and Kinesiology, University of Illinois at Urbana-Champaign, Urbana, IL, United States. Electronic address: mhuibreg@illinois.edu.
Linzie TaylorDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, United States.
Trinidi ProchaskaDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, United States.
Amanda R ArnoldDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, United States.
C Neill EppersonDepartment of Psychiatry, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, United States.
E Britton ChahineDepartment of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA, United States.
Alicia K SmithDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, United States; Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA, United States.
Abigail PowersDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, United States.
Vasiliki MichopoulosDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, United States.
Jennifer S StevensDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, United States.

Funding

Training In Systems And Integrative Biology NeuroscienceT32NS096050 · NINDS · EMORY UNIVERSITY · PI Yoland Smith · 2016 to 2026
$3.9M
Neuroendocrine Mechanisms Underlying Perimenopausal Risk for Trauma-Related Hyperarousal in Black WomenR01MH128244 · NIMH · EMORY UNIVERSITY · PI Vasiliki Michopoulos, Jennifer Strafford Stevens · 2022 to 2026
$3.6M
Sex differences in traumatic brain injury: Neural circuit mediators of overlapping stress and physical effectsF32MH134528 · NIMH · EMORY UNIVERSITY · PI HUIBREGTSE, MEGAN E · 2023 to 2024
$158k
NIMH NIH HHS F32 MH134528NIMH NIH HHS R01 MH128244NINDS NIH HHS T32 NS096050
6 · The paper itself

Abstract

Approximately half of the global population will live to experience the menopausal transition, which is associated with significant quality of life concerns and economic costs. Due to research and funding inequities, there exist significant gaps in knowledge about the menopausal transition and how to improve health outcomes. One tool that is needed to push women's health research forward is the ability to prospectively and accurately identify reproductive stage throughout the female lifespan. In the current paper we review the current criteria for reproductive staging and historical research methods of determining stage, including retrospective and prospective approaches. We discuss important considerations surrounding recall intervals, limitations of the 2011 Stages of Reproductive Aging Workshop + 10 (STRAW+10) criteria, and data privacy concerns. We provide recommendations for the design and execution of future studies, including digital data processing algorithms that can clearly implement operational definitions of STRAW+ 10 reproductive stages. Standardizing STRAW+ 10 terminology and validating methods to collect, process, and analyze prospectively tracked vaginal bleeding data will facilitate more precise and reliable reproductive staging that are critically needed to increase our understanding of how perimenopause increases risk for adverse health outcomes and develop novel interventions to increase quality of life during reproductive aging.

Indexed as

PerimenopauseAgingFemaleHumansLongitudinal StudiesQuality of LifeWomen's HealthLongitudinal researchPerimenopauseRecommendationsReproductive stagingReview

Identifiers

PMID41576711
PMCPMC13361466

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.