Evidence map›Paper›PMID 41576164›Full record

ArticleScience advances2026

CD318 expression defines a novel subset of human CD8

Jeong-Su Do, Wei-Kai Chen, Yu-Wen Hung, David Arribas-Layton, Congcong Lu, Angel Gu, Enrique Montero, Alexandre M Carmo, Helena Reijonen

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In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jeong-Su DoDepartment of Immunology and Theranostics, City of Hope, Duarte, CA, USA.ORCID 0000-0002-2375-2585
Wei-Kai ChenDepartment of Immunology and Theranostics, City of Hope, Duarte, CA, USA.ORCID 0000-0002-8392-1707
Yu-Wen HungDepartment of Immunology and Theranostics, City of Hope, Duarte, CA, USA.
David Arribas-LaytonDepartment of Immunology and Theranostics, City of Hope, Duarte, CA, USA.
Congcong LuBeckman Research Institute and Arthur Riggs Diabetes & Metabolism Research Institute, City of Hope, Duarte, CA, USA.
Angel GuBeckman Research Institute and Arthur Riggs Diabetes & Metabolism Research Institute, City of Hope, Duarte, CA, USA.ORCID 0009-0009-7093-3918
Enrique MonteroBeckman Research Institute and Arthur Riggs Diabetes & Metabolism Research Institute, City of Hope, Duarte, CA, USA.
Alexandre M CarmoIBMC - Instituto de Biologia Molecular e Celular, Porto, Portugal.
Helena ReijonenDepartment of Immunology and Theranostics, City of Hope, Duarte, CA, USA.ORCID 0000-0002-9386-3918

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CUB domain-containing protein 1 (CDCP1; CD318) is a surface glycoprotein known as a ligand for CD6, primarily studied in tumor immunology where it associates with poor prognosis. CD318 is expressed in myeloid dendritic cells and activated monocytes associated with immunoregulatory functions. Here, selective expression of CD318 on a subset of activated human CD8

Indexed as

CD8-Positive T-LymphocytesT-Lymphocytes, RegulatoryCD4-Positive T-LymphocytesDiabetes Mellitus, Type 1HumansInterleukin-2Lymphocyte ActivationProtein Tyrosine Phosphatase, Non-Receptor Type 11Receptors, Antigen, T-CellSignal TransductionTOR Serine-Threonine KinasesInterleukin-2Protein Tyrosine Phosphatase, Non-Receptor Type 11PTPN11 protein, humanReceptors, Antigen, T-CellTOR Serine-Threonine Kinases

Identifiers

PMID41576164
PMCPMC12829577

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.