Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
21 authors.
Le Shi *State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Sun Yat-Sen University, Guangzhou 510060, China.ORCID 0009-0004-2751-1174
Zehui Sun *State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Sun Yat-Sen University, Guangzhou 510060, China.ORCID 0000-0003-3040-4279
Yingxue CaoState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Sun Yat-Sen University, Guangzhou 510060, China.ORCID 0009-0004-0365-8462
Yuying LiState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Sun Yat-Sen University, Guangzhou 510060, China.ORCID 0009-0003-5475-7455
Wenjie QingState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Sun Yat-Sen University, Guangzhou 510060, China.ORCID 0009-0005-4497-7010
Lingli ZhouDepartment of Ophthalmology, Johns Hopkins School of Medicine, Baltimore, MD 21287.ORCID 0000-0002-9321-9348
Mingming XuState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Sun Yat-Sen University, Guangzhou 510060, China.ORCID 0009-0001-3110-5871
Xiaomei MaiState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Sun Yat-Sen University, Guangzhou 510060, China.ORCID 0009-0004-6373-7437
Lechun OuState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Sun Yat-Sen University, Guangzhou 510060, China.
Xiaoping YangDepartment of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21287.
Delaram ShakibaDepartment of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21287.ORCID 0000-0002-3525-9042
Kaoru RiDepartment of Ophthalmology, Johns Hopkins School of Medicine, Baltimore, MD 21287.ORCID 0009-0004-9315-1912
Wangsheng OuState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Sun Yat-Sen University, Guangzhou 510060, China.
Jun ChenDepartment of Immunology and Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.
Avi RosenbergDepartment of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21287.ORCID 0000-0003-2356-950X
Jean-François TrempeDepartment of Pharmacology and Therapeutics and Centre de Recherche en Biologie Structurale, McGill University, Montreal H3G0B1, Canada.ORCID 0000-0002-6543-3371
Edward A FonMcGill Parkinson Program, Neurodegenerative Diseases Group, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal H3A2B4, Canada.ORCID 0000-0002-5520-6239
Xialin LiuState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Sun Yat-Sen University, Guangzhou 510060, China.ORCID 0000-0003-2086-5805
Yihai CaoDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm 17177, Sweden.ORCID 0000-0003-1308-0065
Elia J DuhDepartment of Ophthalmology, Johns Hopkins School of Medicine, Baltimore, MD 21287.ORCID 0000-0003-1917-373X
Wei YiState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Sun Yat-Sen University, Guangzhou 510060, China.ORCID 0000-0003-0943-7244
Funding
Wilmer Core Grant for Vision ResearchP30EY001765 · NEI · JOHNS HOPKINS UNIVERSITY · PI JEFFREY MUMM · 1985 to 2026
$22.1M
Soluble guanylate cyclase in diabetic retinopathyR01EY035549 · NEI · JOHNS HOPKINS UNIVERSITY · PI ELIA J DUH · 2024 to 2026
$1.4M
Reparative angiogenesis in ischemic retinopathyR01EY035897 · NEI · JOHNS HOPKINS UNIVERSITY · PI ELIA J DUH · 2024 to 2026
$1.2M
Bureau of Science and Information Technology of Guangzhou Municipality | Guangzhou Municipal Science and Technology Program key projects (Guangzhou Science and Technology Program key projects) 2024B01J1121Bureau of Science and Information Technology of Guangzhou Municipality | Guangzhou Municipal Science and Technology Project (Guangzhou Science and Technology Plan) 2025A03J3988Foundation for the NIH (FNIH) R01EY035549Foundation for the NIH (FNIH) R01EY035897GDSTC | Special Project for Research and Development in Key areas of Guangdong Province () 2023B1111050004HHS | NIH (NIH) P30EY001765MOST | National Key Research and Development Program of China (NKPs) 2018YFA0108300MOST | National Natural Science Foundation of China (NSFC) 82101329MOST | National Natural Science Foundation of China (NSFC) 82271095
6 · The paper itself
Abstract
Mitochondrial dysfunction is a hallmark of aging and a key contributor to age-related diseases including cardiovascular disease. However, molecular pathways that safeguard mitochondrial homeostasis in the aging heart remain poorly understood. Here, we identify MTFR1L as a regulator of mitophagy that binds p-S65-Ub, a key signal amplifying the PINK1/Parkin axis. We find that MTFR1L is enriched in metabolically active tissues, particularly in the heart, where it regulates Parkin signaling. Genetic deletion of
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
MTFR1L is a cardiac antiaging factor for maintenance of mitochondrial homeostasis. · full record | OpenQuestion