ArticleProceedings of the National Academy of Sciences of the United States of America2026
Cortical O
Hongyi Kang, Sitong Zhou, Michael Giannetto, Evan D McConnell, Ning Kang, Qian Sun, Hetince Zhao, Helen S Wei, Kevin Kramer, Yaojun Guo and 4 more
Abstract read
In one paragraphArticle in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
14 authors.
Hongyi Kang *Department of Neurosurgery, Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642.
Sitong Zhou *Department of Chemical Engineering, University of California, Davis, CA 95616.
Michael GiannettoDepartment of Neurosurgery, Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642.
Evan D McConnellDepartment of Neurosurgery, Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642.
Ning KangDepartment of Neurosurgery, Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642.
Qian SunDepartment of Neurosurgery, Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642.
Hetince ZhaoDepartment of Ophthalmology, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY 11794.ORCID 0000-0003-4383-3582 Kevin KramerDepartment of Biomedical Engineering, University of California, Davis, CA 95616.
Juliana S CostaDepartment of Anatomy and Bakar Aging Research Institute, University of California, San Francisco, CA 94143.
Saul A VilledaDepartment of Anatomy and Bakar Aging Research Institute, University of California, San Francisco, CA 94143.ORCID 0000-0002-2726-9582 Maiken NedergaardDepartment of Neurosurgery, Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642.ORCID 0000-0001-6502-6031 Jiandi WanDepartment of Neurosurgery, Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642.ORCID 0000-0002-7250-975X Funding
Viral Tool Development Core: Visualization and manipulation of brain fluid dynamics by recombinant viral vectorsU19NS128613 · NINDS · UNIVERSITY OF ROCHESTER · PI Laura Diane Lewis · 2022 to 2026
$13.6MHHS | NIH | National Institute on Aging (NIA) AG086041HHS | NIH (NIH) 1RF1 NS110049-01NINDS NIH HHS U19 NS128613
6 · The paper itselfAbstract
Current evidence suggests that the rejuvenating effects of parabiosis on brain function arise from the exchange of blood factors that enhance synaptic plasticity, promote neurogenesis, and reduce neuroinflammation in aged animals. However, aging is also associated with diminished tissue oxygenation. Here, we report that erythrocytes (red blood cells, RBCs) from aged mice exhibit reduced responsiveness to low oxygen tension (PO
Indexed as
AgingCerebral CortexOxygenAnimalsCerebrovascular CirculationErythrocytesMaleMiceMice, Inbred C57BLParabiosisOxygencapillarycerebral blood flowmicrofluidicneurodegenerationneurovascular coupling
Identifiers
PMID41576091
PMCPMC12846828
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390