ArticleProceedings of the National Academy of Sciences of the United States of America2026
RecBCD-dependent post-UV replication restart in
Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Topoisomerase III limits RecA-dependent DNA amplification in the chromosome terminus with RecG.Nucleic acids research · 2026Article
- Processing of Reversed Replication Forks is Required for the Resolution of Replication-Transcription Conflicts.bioRxiv : the preprint server for biology · 2026Article
- RecBCD-dependent post-UV replication restart inProceedings of the National Academy of Sciences of the United States of America · 2026Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Ultraviolet (UV) irradiation induces pyrimidine dimers in DNA, which block replication, but are efficiently removed by excision, allowing replication restart. Interestingly, soon after restart, the cells become capable of inducible stable DNA replication (iSDR) without new origin-initiations-suggesting unusual replication topology. The original idea was that the preexisting forks remain dormant even after UV-lesion removal, and when the new origin-initiated forks arrive, they rear-end the dormant forks, creating potential for iSDR. While there is origin-overinitiation after UV, the current idea is that preexisting forks are restarted-making the iSDR potential unclear. We used replication profiling of post-UV cells to investigate reactivation of UV-blocked forks. To compare profile time-sequences, we developed indexation procedure generating nested profile sets. Wild type nested set shows: 1) no replication during the first 30 min post-UV; 2) overinitiation from the origin combined with restart of preexisting forks during the next 30 min post-UV. The restart required RecBCD enzyme to repair double-strand breaks, confirming that the UV-stalled forks disintegrate and need recombinational repair to restart. Preexisting fork restart is separate from new origin-initiations by DnaA, as the
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.