ArticleProceedings of the National Academy of Sciences of the United States of America2026
Gpr171 regulates embryonic hematopoietic stem cell emergence via ERK1/2 and Notch signaling.
Kun Zhou, Hongyan Liu, Kai Zhu, Longhai Yu, Peng-Fei Xu, Yan Li
Abstract read
In one paragraphArticle in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
6 authors.
Kun Zhou *Key Laboratory of Animal Virology, Ministry of Agricultural and Rural Affairs of China and Zhejiang Provincial Engineering Research Center of Animal Biological Products, Department of Veterinary Medicine, Zhejiang University College of Animal Sciences, Hangzhou, Zhejiang 310058, China.
Hongyan Liu *Key Laboratory of Animal Virology, Ministry of Agricultural and Rural Affairs of China and Zhejiang Provincial Engineering Research Center of Animal Biological Products, Department of Veterinary Medicine, Zhejiang University College of Animal Sciences, Hangzhou, Zhejiang 310058, China.
Kai Zhu *Key Laboratory of Animal Virology, Ministry of Agricultural and Rural Affairs of China and Zhejiang Provincial Engineering Research Center of Animal Biological Products, Department of Veterinary Medicine, Zhejiang University College of Animal Sciences, Hangzhou, Zhejiang 310058, China.
Longhai YuKey Laboratory of Animal Virology, Ministry of Agricultural and Rural Affairs of China and Zhejiang Provincial Engineering Research Center of Animal Biological Products, Department of Veterinary Medicine, Zhejiang University College of Animal Sciences, Hangzhou, Zhejiang 310058, China.
Peng-Fei XuCenter for Genetic Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, Zhejiang University, Yiwu, Zhejiang 322000, China.ORCID 0000-0002-7318-8548 Yan LiKey Laboratory of Animal Virology, Ministry of Agricultural and Rural Affairs of China and Zhejiang Provincial Engineering Research Center of Animal Biological Products, Department of Veterinary Medicine, Zhejiang University College of Animal Sciences, Hangzhou, Zhejiang 310058, China.ORCID 0000-0003-4813-5783 Funding
MOST | National Natural Science Foundation of China (NSFC) 31872837MOST | National Natural Science Foundation of China (NSFC) 32102620
6 · The paper itselfAbstract
Hematopoietic stem cells (HSCs), which sustain lifelong blood cell production, emerge from hemogenic endothelium during embryonic development through the regulation of multiple signaling pathways. However, generating functional HSCs in vitro remains challenging, underscoring gaps in understanding the underlying mechanisms. Here, we identify GPR171, a P2Y-family G-protein-coupled receptor (GPCR), as a critical regulator of vertebrate embryonic HSC specification.
Indexed as
Hematopoietic Stem CellsMAP Kinase Signaling SystemReceptors, G-Protein-CoupledReceptors, NotchZebrafish ProteinsAnimalsHematopoiesisHumansMiceMitogen-Activated Protein Kinase 1Signal TransductionZebrafishMitogen-Activated Protein Kinase 1Receptors, G-Protein-CoupledReceptors, NotchZebrafish ProteinsERK1/2Gpr171hematopoietic stem cellsNotchpcsk1nl
Identifiers
PMID41576080
PMCPMC12846792
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