Evidence map›Paper›PMID 41576072›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Generalizations of the quadratic bound optimization principle.

Xun-Jian Li, Guo-Liang Tian, Hua Zhou, Kenneth Lange

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Xun-Jian Li *Department of Biostatistics, University of California, Los Angeles, CA 90095.ORCID 0000-0001-6433-741X
Guo-Liang TianDepartment of Statistics and Data Science, Southern University of Science and Technology, Guangdong Province 518055, People's Republic of China.
Hua ZhouDepartment of Biostatistics, University of California, Los Angeles, CA 90095.ORCID 0000-0003-1320-7118
Kenneth Lange *Department of Computational Medicine, University of California, Los Angeles, CA 90095.ORCID 0000-0002-1313-5030

Funding

Genomics, GPUs, and Next Generation Computational StatisticsR01HG006139 · NHGRI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SOBEL, ERIC · 2011 to 2023
$5.1M
Modeling, Inference, and Optimization for Genomic and Biomedical Big DataR35GM141798 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LANGE, KENNETH L · 2021 to 2025
$2.7M
Transforming Precision Medicine: Dynamic Learning and Prediction of Disease Progression in Massive, Diverse, and Multimodal CohortsR01DK142026 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GANG LI, Hua Zhou · 2025 to 2026
$1.1M
MOST | National Natural Science Foundation of China (NSFC) 12171225National Science Foundation (NSF) DMS 2054253; IIS 2205441NHGRI NIH HHS R01 HG006139NIDDK NIH HHS R01 DK142026NIGMS NIH HHS R35 GM141798
6 · The paper itself

Abstract

The quadratic bound (QB) principle proposed by Böhning and Lindsay in 1988 is an important special case of the majorization-minimization or minorization-maximization optimization principle. The quadratic upper-bound (QUB) principle is pertinent to minimization; the analogous quadratic lower-bound principle is pertinent to maximization. Unfortunately, in minimizing a loss [Formula: see text], the QUB principle is limited by the difficulty of finding a constant positive definite matrix [Formula: see text] such that [Formula: see text] is positive semidefinite for all [Formula: see text]. This paper proposes a generalization of the QB principle that avoids this limitation. In particular, we construct QUB algorithms by replacing the matrix [Formula: see text] by a continuous matrix-valued function [Formula: see text] that dominates the Hessian [Formula: see text] and depends on the both the current iterate [Formula: see text] and the next potential iterate [Formula: see text]. In practice, we require [Formula: see text] to be diagonal with its diagonal entries separated in [Formula: see text]. In other words, the [Formula: see text]th diagonal entry of [Formula: see text] depends on [Formula: see text] only through its [Formula: see text]th entry [Formula: see text]. Theoretical analysis confirms that this class of generalized QB algorithms enjoys global convergence in favorable circumstances. For the scalar case, the tangency condition that the second derivative equals the bound function at the current point promotes superlinear convergence. Several numerical experiments implemented in Julia illustrate the power of the generalized QB principle.

Indexed as

diagonal matrix-valued functionleast squaresmaximum likelihood estimationMM algorithmquadratic bound principle

Identifiers

PMID41576072
PMCPMC12846767

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.