Evidence map›Paper›PMID 41576067›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Nitrate-induced NLP1 SUMOylation regulates nitrate signaling and root nodulation.

Jing Liu, Zhenpeng Luo, Jiang Wang, Jieshun Lin, Fang Xie

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Homeostasis of ammonium and nitrate in plants.Quantitative plant biology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jing LiuCAS Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, China.ORCID 0000-0002-5092-7627
Zhenpeng LuoCAS Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, China.ORCID 0000-0002-4512-8505
Jiang WangCAS Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, China.ORCID 0000-0002-2648-5355
Jieshun LinDepartment of Biological Sciences, National University of Singapore, Singapore 117543, Singapore.
Fang XieCAS Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, China.ORCID 0000-0002-0530-1430

Funding

MOST | National Key Research and Development Program of China (NKPs) 2024YFA0918200MOST | National Natural Science Foundation of China (NSFC) 32470248 32100194STI 2030-Major Projects 2023ZD04072Straegic Priority Research Program of Chinese Academy of Sciences XDB0630103
6 · The paper itself

Abstract

Nitrate serves both as an essential nutrient and a key signaling molecule that shapes plant growth. In legumes, high nitrate concentrations suppress symbiotic nitrogen fixation, a process mediated by MtNLP1 (NIN-like protein1). Although nitrate minimally affects NLP transcript levels, it strongly controls their nuclear localization. How posttranslational modifications regulate MtNLP1 function, however, has remained unclear. Here, we show that nitrate induces SUMOylation of MtNLP1 at lysine 589 and 795 and that this modification is essential for its biological activity. Loss of these SUMO sites compromises nitrate-mediated inhibition of nodulation and weakens MtNLP1 interactions with MtNIN and itself. Components of the SUMOylation machinery in

Indexed as

Arabidopsis ProteinsMedicago truncatulaNitratesPlant ProteinsPlant Root NodulationSignal TransductionSumoylationArabidopsisGene Expression Regulation, PlantPlant RootsSymbiosisTranscription FactorsArabidopsis ProteinsNIN-LIKE PROTEIN7, ArabidopsisNitratesPlant ProteinsTranscription FactorsNLP1SUMOylationsymbiotic nitrogen fixationtranscription factor

Identifiers

PMID41576067
PMCPMC12846804

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.