ArticlePloS one2026
Increased brain coverage and efficiency when measuring current-induced magnetic fields by use of simultaneous multi-slice echo-planar MRI.
Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeMagnetic resonance current density imaging (MRCDI) can non-invasively validate electric field simulations in volume conductor head models. Weak electric currents are injected using scalp electrodes while measuring the MR phase perturbations caused by the tiny magnetic fields (1-2 nT) induced by the current flow in tissue. MRCDI generally has a low signal-to-noise ratio, making it susceptible to technical imperfections and physiological noise. In this technical note, we tested and optimized simultaneous multi-slice (SMS) EPI for time-efficient and robust brain MRCDI.
methodsMRCDI data was acquired in a phantom and five human brains using SMS-EPI optimized for measuring current-induced phase perturbations. Multiband factors and interslice gaps were systematically varied and the resulting image quality assessed. In particular, the impact of interslice signal leakage on the measured phase was tested.
resultsCurrent-free acquisitions showed the expected noise amplification with decreasing interslice distances. However, physiological noise generally dominated the human data, masking potential SMS-related penalties and making the overall noise levels identical to single-slice EPI for interslice gaps of at least 12 mm and multiband factors between 3 and 5. Upon application of electric currents, the phantom data revealed subtle artifacts for multiband factors 5 and 6, even for large gaps. Nevertheless, artifacts were absent in the human brain for multiband factors up to 5, where the performance of SMS-EPI approached that of single-slice measurements for sufficient interslice distances.
conclusionOptimized SMS-EPI with multiband factors up to 5 and minimum interslice gaps of 12 mm performs on par with single-slice EPI, making it attractive for increasing brain coverage in MRCDI.
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