ArticlePloS one2026
Bio-waste derived fluorescent carbon dots based biodegradable mechanically strong hydrogel for stimuli-responsive nonsteroidal anti-inflammatory drug (NSAID) delivery.
Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Comparative efficacy of transdermal buprenorphine versus diclofenac in the management of knee osteoarthritis: a randomized controlled trial with network pharmacology insights.Inflammopharmacology · 2026Trial
- Green Synthesis of Fluorescent Carbon Dots and AI-Driven New Paradigms: A Comprehensive Review.Biosensors · 2026Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, biowaste derived carbon dots (BCDs) were synthesized from sugarcane bagasse via a hydrothermal route and incorporated into biodegradable, mechanically robust hydrogels for stimuli-responsive nonsteroidal anti-inflammatory drug (NSAID) delivery. BCDs, characterized by FTIR, Raman spectroscopy, and photoluminescence analyses, exhibited abundant surface functional groups and excellent fluorescence properties. The integration of BCDs into the hydrogel matrix enhanced the mechanical strength, imparted pH-responsive drug release behavior, and maintained the structural integrity under physiological conditions. In vitro release studies using ibuprofen as a model drug demonstrated faster release under acidic conditions (pH 3.8) than under neutral and alkaline pH, aligning with pathological microenvironments. The drug release kinetics were best described by the Higuchi model, indicating a diffusion-controlled mechanism. Cytotoxicity assays confirmed the high biocompatibility of both free BCDs and BCD-loaded hydrogels, with sustained cell viability over five days. The combination of bio-derived nanomaterials, tunable release properties, and excellent cytocompatibility highlight the potential of this system for targeted and environmentally sustainable drug delivery applications. This approach provides a scalable and green route for developing advanced biomedical platforms from agricultural waste with significant implications for controlled drug release and tissue-compatible therapeutic interventions.
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Registered trials
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