ArticlePloS one2026
Formononetin ameliorates SP-induced urticaria in mice via suppressing TAK1/MAK signaling pathway.
Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundChronic idiopathic urticaria (CIU) is a condition that significantly impacts patient well-being, requiring effective therapeutic strategies. Formononetin, a natural isoflavone with anti-inflammatory properties, has shown promise in allergic conditions. However, its specific effects and mechanism in CIU are not fully understood.
methodsComparative analyses were conducted between normal and formononetin-treated groups, along with mechanistic investigations into the TAK1/MAPK pathway both in vivo and in vitro. Cell morphology, cytokine secretion, histamine release, and TAK1/MAPK pathway alterations were assessed.
resultsFormononetin treatment led to a dose-dependent reduction in MC degranulation, histamine release, and secretion of inflammatory cytokines (TNF-α, IL-1β, IL-6). Additionally, formononetin inhibited the phosphorylation of TAK1, p38, ERK1, and JNK similar to a TAK1 inhibitor in murine and cellular models.
conclusionFormononetin shows potential as an anti-allergic agent by alleviating inflammatory responses in CIU through suppression of the TAK1/MAPK pathway in both murine models and MC/9 cells.
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