Evidence map›Paper›PMID 41575982›Full record

ArticleJournal of proteome research2026

Plasma Proteomic Profiling Identifies a Six-Protein Panel for Grading and Predicting Intervertebral Disc Degeneration.

Ziyue Zhou, Yinkun Li, Lin Zhu, Hui Li, Nannan Wang, Haiyuan Zhou, Jingzi Zhang, Lei Fang, Sen Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of proteome research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ziyue ZhouDivision of Spine Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospita, Affiliated Hospital of Medical School, Medical School of Nanjing University, Zhongshan Road 321, Nanjing 210008, China.
Yinkun LiDivision of Spine Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospita, Affiliated Hospital of Medical School, Medical School of Nanjing University, Zhongshan Road 321, Nanjing 210008, China.
Lin ZhuDepartment of Spine Surgery, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Zhongshan Road 321, Nanjing 210008, China.
Hui LiDepartment of Radiology, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Zhongshan Road 321, Nanjing 210008, China.
Nannan WangState Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Key Laboratory of Molecular Medicine, Chemistry and Biomedicine Innovation Center, Medical School of Nanjing University, Hankou Road 22, Nanjing 210093, China.
Haiyuan ZhouState Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Key Laboratory of Molecular Medicine, Chemistry and Biomedicine Innovation Center, Medical School of Nanjing University, Hankou Road 22, Nanjing 210093, China.
Jingzi ZhangDivision of Spine Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospita, Affiliated Hospital of Medical School, Medical School of Nanjing University, Zhongshan Road 321, Nanjing 210008, China.
Lei FangDivision of Spine Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospita, Affiliated Hospital of Medical School, Medical School of Nanjing University, Zhongshan Road 321, Nanjing 210008, China.ORCID 0000-0002-2582-4845
Sen LiDivision of Spine Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospita, Affiliated Hospital of Medical School, Medical School of Nanjing University, Zhongshan Road 321, Nanjing 210008, China.ORCID 0000-0002-4819-097X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intervertebral disc degeneration (IDD) represents a significant health concern affecting a large portion of the population and leads to chronic pain and disability. Despite the prevalence of this condition, the underlying biological mechanisms and potential biomarkers for early diagnosis remain inadequately understood. Advances in proteomics have opened new avenues for identifying blood biomarkers that can facilitate better diagnostic and therapeutic strategies. The primary aim of this study was to identify and validate specific plasma proteins associated with varying grades of IDD. This case-control study compared plasma samples from patients with grade II (

Indexed as

Blood ProteinsIntervertebral Disc DegenerationProteomicsAdultBiomarkersCase-Control StudiesEnzyme-Linked Immunosorbent AssayFemaleHumansMaleMiddle AgedProteomeBiomarkersBlood ProteinsProteomebiomarkerintervertebral disc degenerationmachine learningplasma proteomicspredictive modelreceiver operating characteristic

Identifiers

PMID41575982
PMCPMC12888008

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.