Evidence map›Paper›PMID 41575893›Full record

ArticleChemistry & biodiversity2026

Investigating the Cytotoxic Potential of Omphalodes cappadocica (Willd.) DC. on Breast Cancer Cells by Phytochemical-Based Molecular Docking Studies: A Comparative Study of Aerial Parts and Roots.

İçim Gökkaya, Ceylan Hepokur, Okan Aykaç, Elif Karaman, Oguz Cakir, Abbas Tarhan, Mustafa Abdullah Yılmaz, Gülin Renda

Abstract readComparative Study
In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

İçim GökkayaDepartment of Pharmaceutical Botany, Faculty of Pharmacy, Karadeniz Technical University, Trabzon, Türkiye.ORCID https://orcid.org/0000-0003-0803-2886
Ceylan HepokurDepartment of Biochemistry, Faculty of Pharmacy, Sivas Cumhuriyet University, Sivas, Türkiye.
Okan AykaçInstitute of Health Sciences, Inonu University, Malatya, Türkiye.
Elif KaramanDepartment of Pharmacognosy, Faculty of Pharmacy, Karadeniz Technical University, Trabzon, Türkiye.
Oguz CakirDepartment of Nutrition and Dietetics, Faculty of Health Sciences, Dicle University, Diyarbakir, Türkiye.
Abbas TarhanDicle University Science and Technology Research and Application Center, Diyarbakir, Türkiye.
Mustafa Abdullah YılmazDicle University Science and Technology Research and Application Center, Diyarbakir, Türkiye.
Gülin RendaDepartment of Pharmacognosy, Faculty of Pharmacy, Karadeniz Technical University, Trabzon, Türkiye.ORCID https://orcid.org/0000-0001-6323-0338

Funding

This study was supported by the Scientific and Technological Research Council of Türkiye, TUBITAK (TUBITAK 2209-A program) (Project number: 1919B012406444).
6 · The paper itself

Abstract

This study aims to evaluate the potential effects of Omphalodes cappadocica on a breast cancer cell line for the first time. The methanol extract of the aerial parts (Ae-M) exhibited the strongest cytotoxicity against MCF-7 and MDA-MB-231 cells after 48 h of incubation, with IC

Indexed as

Antineoplastic Agents, PhytogenicBreast NeoplasmsMolecular Docking SimulationPhytochemicalsPlant Components, AerialPlant ExtractsPlant RootsCell ProliferationCell SurvivalDose-Response Relationship, DrugDrug Screening Assays, AntitumorFemaleHumansMCF-7 CellsMDA-MB-231 CellsMolecular StructureAntineoplastic Agents, PhytogenicPhytochemicalsPlant Extractsin silicoMCF‐7MDA‐MB‐231Omphalodes cappadocicaphytochemical analysis

Identifiers

PMID41575893
PMCPMC13420771

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.