Evidence map›Paper›PMID 41575878›Full record

ArticleChemistry & biodiversity2026

Comprehensive In Vitro and In Silico Evaluation of Foeniculum vulgare Seeds: Phytochemicals, Antioxidant Power, Antimicrobial Action, and Anticoagulant Activity.

Aziz Drioiche, Omkulthom Al Kamaly, Mohamed El Ouardi, Nadia Handaq, Ahde El Imache, Fouad El-Akhal, Fadoua El Makhoukhi, Adil Maleb, El Ouali Lalami Abdelhakim, Sevser Sahpaz and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Aziz DrioicheHigher Institute of Nursing Professions and Health Techniques of Fez, Regional Health Directorate Fez-Meknes, EL Ghassani Hospital, Fez, Morocco.ORCID https://orcid.org/0000-0001-9036-5289
Omkulthom Al KamalyDepartment of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah Bint Abdulrahman. University, Riyadh, Saudi Arabia.
Mohamed El OuardiResearch Team of Chemistry of Bioactive Molecules and the Environment, Laboratory of Innovative Materials and Biotechnology of Natural Resources, Faculty of Sciences, Moulay Ismaïl University, Meknes, Morocco.
Nadia HandaqResearch Team of Chemistry of Bioactive Molecules and the Environment, Laboratory of Innovative Materials and Biotechnology of Natural Resources, Faculty of Sciences, Moulay Ismaïl University, Meknes, Morocco.
Ahde El ImacheLaboratory of Innovative Technologies, Process Engineering Department, Higher School of Technology Fez, USMBA, Fez, Morocco.
Fouad El-AkhalHigher Institute of Nursing Professions and Health Techniques of Fez, Regional Health Directorate Fez-Meknes, EL Ghassani Hospital, Fez, Morocco.
Fadoua El MakhoukhiFaculty of Science, Laboratory of Spectroscopy, Molecular Modelling, Materials, Nanomaterial, Water and Environment, CERNE2D, Mohammed V University in Rabat, Rabat, Morocco.
Adil MalebMicrobiology Unit, Laboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Faculty of Medicine and Pharmacy of Oujda, University Mohammed Premier, Oujda, Morocco.
El Ouali Lalami AbdelhakimHigher Institute of Nursing Professions and Health Techniques of Fez, Regional Health Directorate Fez-Meknes, EL Ghassani Hospital, Fez, Morocco.
Sevser SahpazUniv. Lille, University of Liège, University of Picardie Jules Verne, JUNIA, UMRT 1158 BioEcoAgro, Specialized Metabolites of Plant Origin, Lille, France.
Touriya ZairResearch Team of Chemistry of Bioactive Molecules and the Environment, Laboratory of Innovative Materials and Biotechnology of Natural Resources, Faculty of Sciences, Moulay Ismaïl University, Meknes, Morocco.

Funding

Princess Nourah Bint Abdulrahman University PNURSP2025R917
6 · The paper itself

Abstract

Foeniculum vulgare was investigated for the comparative phytochemical profiles and bioactivities of its aqueous extracts (decoction, E1; Soxhlet, E2) and essential oil (EO), together with in silico exploration of major constituents. Phenolics, flavonoids, and tannins were quantified spectrophotometrically, individual metabolites profiled by HPLC/UV-ESI-MS, and volatile components by GC-MS. Antioxidant capacity (DPPH, FRAP, TAC), antimicrobial activity (MIC/MBC or MFC against 29 bacteria and 8 fungi), and anticoagulant effects (prothrombin time [PT] and activated partial thromboplastin time [aPTT]) were assessed. Molecular docking targeted β-lactamases (OXA-10), thrombin, and myeloperoxidase. The decoction (E1) showed the highest phenolic (56.8 mg GAE/g) and flavonoid (22.8 mg QE/g) contents and superior radical-scavenging activity (DPPH IC

Indexed as

Anti-Bacterial AgentsAnticoagulantsAnti-Infective AgentsAntioxidantsFoeniculumPhytochemicalsSeedsBacteriaBiphenyl CompoundsFungiHumansMicrobial Sensitivity TestsMolecular Docking SimulationPicratesPlant ExtractsAnti-Bacterial AgentsAnticoagulantsAnti-Infective AgentsAntioxidantsBiphenyl CompoundsPhytochemicalsPicratesPlant ExtractsanticoagulantantimicrobialantioxidantE‐anetholeFoeniculum vulgaremolecular dockingquercetin‐3‐glucuronide

Identifiers

PMID41575878
PMCPMC13420826

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.