SynthesisJournal of thrombosis and thrombolysis2026
Sonothrombolysis as an adjunct to primary PCI in STEMI: a systematic review and meta-analysis of randomized trials.
Synthesis in Journal of thrombosis and thrombolysis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Beyond radiotheranostics: how imaging modality defines theranostics.European radiology experimental · 2026Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study evaluates the role of ultrasound-mediated thrombolysis (sonothrombolysis) as an adjunct to percutaneous coronary intervention (PCI) in patients with ST-elevated myocardial infarction (STEMI). A comprehensive literature search was conducted across five databases, identifying randomized controlled trials (RCTs) assessing sonothrombolysis in addition to PCI in STEMI patients. Data analysis employed a random effects model in R, focusing on outcomes like left ventricular ejection fraction (LVEF), end diastolic volume (LVEDV), systolic volume (LVESV), left ventricular global longitudinal strain (LV-GLS), and infarct size, evaluated at multiple time points. Six RCTs evaluated sonothrombolysis combined with PCI (241 patients) versus PCI alone (232 patients). LVEF was significantly higher in the sonothrombolysis group immediately post-PCI (MD: 4.00; 95% CI: 1.62, 6.38; P = 0.001) and at subsequent time points (MD: 4.06-4.39; P < 0.01). LVEDV and LVESV were significantly lower at 48-72 h and 6 months in the sonothrombolysis group. LV-GLS was consistently higher across all time points. Infarct size was notably smaller in the sonothrombolysis arm across all time points (MD: - 5.41, 95%CI: [- 8.82, - 2.00]; p = 0.0018). Sonothrombolysis significantly improves cardiac outcomes following PCI in STEMI patients, showcasing better LVEF, lower LVEDV and LVESV, and reduced infarct size. Further exploration of its standalone and adjunctive potential with PCI is warranted.
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Registered trials
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