Evidence map›Paper›PMID 41575717›Full record

ArticleJournal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing2026

Left bundle branch area pacing decreased the pressure gradient and severity of tricuspid regurgitation compared with right ventricular pacing.

Yi-Ting Chen, Yu-Sheng Lin, Po-Wei Yang, Uei Chen, Yung-Lung Chen, Mien-Cheng Chen, Huang-Chung Chen

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Yi-Ting Chen *Division of Cardiology, Department of Internal MedicineCollege of MedicineNiao-Song District, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University, 123, Ta-Pei Road, Kaohsiung City, 83301, Taiwan.
Yu-Sheng Lin *Division of Cardiology, Department of Internal MedicineCollege of MedicineNiao-Song District, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University, 123, Ta-Pei Road, Kaohsiung City, 83301, Taiwan.
Po-Wei YangDivision of Cardiology, Department of Internal MedicineCollege of MedicineNiao-Song District, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University, 123, Ta-Pei Road, Kaohsiung City, 83301, Taiwan.
Uei ChenDivision of Cardiology, Department of Internal MedicineCollege of MedicineNiao-Song District, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University, 123, Ta-Pei Road, Kaohsiung City, 83301, Taiwan.
Yung-Lung ChenDivision of Cardiology, Department of Internal MedicineCollege of MedicineNiao-Song District, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University, 123, Ta-Pei Road, Kaohsiung City, 83301, Taiwan.
Mien-Cheng ChenDivision of Cardiology, Department of Internal MedicineCollege of MedicineNiao-Song District, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University, 123, Ta-Pei Road, Kaohsiung City, 83301, Taiwan.
Huang-Chung ChenDivision of Cardiology, Department of Internal MedicineCollege of MedicineNiao-Song District, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University, 123, Ta-Pei Road, Kaohsiung City, 83301, Taiwan. chc3@cgmh.org.tw.ORCID http://orcid.org/0000-0002-4423-9246

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRight ventricular pacing (RVP) is associated with the progression of tricuspid regurgitation (TR). Left bundle branch area pacing (LBBAP) has been considered a more physiological procedure. Hence, we aimed to investigate the TR variation and associated clinical outcomes after LBBAP implantation.

methodsWe retrospectively analyzed 492 patients receiving a new pacemaker implantation between 2018 January and 2024 December, consisting of 241 patients with LBBAP and 251 patients with RVP. Primary outcomes were the deterioration or regression of TR grade, and the progression of tricuspid regurgitation pressure gradient (TRPG).

resultsDuring a mean follow-up period of 2.17 ± 0.87 years, the LBBAP group had a lower incidence of TRPG progression (P = 0.010), and a higher incidence of TR regression (P = 0.016) compared with the RVP group. Kaplan–Meier survival curve analysis revealed that the LBBAP group had a lower cumulative incidence of TRPG progression compared with the RVP group (Log-rank test, P = 0.023). Furthermore, the patients with TRPG progression had a higher cumulative incidence of heart failure hospitalization compared with those without TRPG progression (Log-rank test, P < 0.001). Only in patients with heart failure with reduced ejection fraction, the incidence of TR progression was lower in the LBBAP group than the RVP group (P = 0.019).

conclusionsIn this study, we found that LBBAP, compared with RVP, may prevent TRPG progression, have the benefit of TR improvement, and decrease TR progression in patients with heart failure with reduced ejection fraction, probably leading to decrease heart failure hospitalization.

Indexed as

Cardiac Pacing, ArtificialHeart VentriclesTricuspid Valve InsufficiencyAgedDisease ProgressionFemaleHeart FailureHumansMaleRetrospective StudiesSeverity of Illness IndexTreatment OutcomeHeart failure hospitalizationLeft bundle branch area pacingNon-apical right ventricular pacingTricuspid regurgitationTricuspid regurgitation pressure gradient

Identifiers

PMID41575717
PMCPMC13221372

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.