Evidence map›Paper›PMID 41575708›Full record

ArticleAIDS and behavior2026

PrEP as a "Hidden Message": The Impact of Partner Dynamics on Oral PrEP Adherence Among Cisgender Women in Serodiscordant Relationships.

Thupten D Phuntsog, Jamila K Stockman, K Rivet Amico, Ryan Kofron, Sheldon Morris, Raphael J Landovitz, Steffanie Strathdee, David J Moore, Jill Blumenthal

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Thupten D PhuntsogSchool of Public Health and Health Sciences, University of Massachusetts Amherst, Amherst, MA, USA.
Jamila K StockmanDepartment of Medicine, University of California San Diego, San Diego, CA, 92103, USA.
K Rivet AmicoDepartment of Health Behavior and Health Equity, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Ryan KofronUCLA Center for Clinical AIDS Research & Education, University of California Los Angeles, Los Angeles, CA, USA.
Sheldon MorrisDepartment of Medicine, University of California San Diego, San Diego, CA, 92103, USA.
Raphael J LandovitzUCLA Center for Clinical AIDS Research & Education, University of California Los Angeles, Los Angeles, CA, USA.
Steffanie StrathdeeDepartment of Medicine, University of California San Diego, San Diego, CA, 92103, USA.
David J MooreDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Jill BlumenthalDepartment of Medicine, University of California San Diego, San Diego, CA, 92103, USA. jblumenthal@health.ucsd.edu.ORCID http://orcid.org/0000-0002-2307-9108

Funding

California HIV/AIDS Research Program E111-LA-002BCalifornia HIV/AIDS Research Program EI11-SD-005BCenter for AIDS Research, University of California Los Angeles 5P30AI028697NIH HHS TR001444
6 · The paper itself

Abstract

backgroundHeterosexual sex accounts for 87% of new HIV diagnoses among cisgender women. We sought to explore the intersection of partner dynamics and oral preexposure prophylaxis (PrEP) adherence among cisgender women in heterosexual serodiscordant relationships.

methodsFrom June 2017-August 2018, we conducted semi-structured in-depth interviews using a social ecological model framework. Twenty cisgender women in serodiscordant relationships, who participated in a PrEP demonstration project to evaluate adherence and retention in San Diego and Los Angeles, participated in in-depth interviews. Interviews were audio-recorded and transcribed, and transcripts were analyzed using thematic analysis.

resultsAmong the 20 participants, the median age was 37.5 years (IQR 32, 48), with n = 6 (30%) identifying as Black and n = 5 (25%) as Hispanic. Sixty-five percent of women had protective drug levels based on real-time tenofovir-diphosphate drug level assays at the study visit prior to their interviews. Some partners played a significant role in PrEP adherence, often showing support by vocalizing encouragement and appreciation, offering reminders to take PrEP, and sometimes administering PrEP. Other partners were unsupportive and discouraged PrEP use, which may have hindered adherence. HIV and PrEP stigma were identified as potential barriers for women to take PrEP and disclose their PrEP use to others.

conclusionsWithin the context of this PrEP demonstration project, partner dynamics impacted PrEP adherence for HIV-negative cisgender women in serodiscordant relationships. We urge further investigation of relationship dynamics and PrEP adherence and persistence specifically among US-based cisgender women.

Indexed as

Anti-HIV AgentsHIV InfectionsMedication AdherencePre-Exposure ProphylaxisSexual PartnersAdministration, OralAdultFemaleHeterosexualityHumansInterviews as TopicLos AngelesMaleMiddle AgedTenofovirAnti-HIV AgentsTenofovirAdherenceCisgender womenPartner dynamicsPre-exposure prophylaxisSerodiscordant relationships

Identifiers

PMID41575708
PMCPMC13303303

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.