Evidence map›Paper›PMID 41575701›Full record

ArticleScience China. Life sciences2026

Lung function impairment and risk of sepsis and sepsis-related mortality: a large cohort study with over 310,000 participants.

Shaokang Xu, Yi Yang, Jian Shi, Ya Miao, Xiaoke Kong, Yiting Tang, Bin Zhao, Fang Fang, Jiaqi Huang, Ben Lu

Abstract read
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In one paragraph

Article in Science China. Life sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shaokang Xu *Department of Critical Care Medicine and Hematology, The Third Xiangya Hospital, Central South University, Changsha, 410000, China.
Yi Yang *National Clinical Research Center for Endocrine and Metabolic Diseases, Metabolic Syndrome Research Center, Key Laboratory of Diabetes Immunology, Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Jian Shi *Department of Critical Care Medicine and Hematology, The Third Xiangya Hospital, Central South University, Changsha, 410000, China.
Ya MiaoNational Clinical Research Center for Endocrine and Metabolic Diseases, Metabolic Syndrome Research Center, Key Laboratory of Diabetes Immunology, Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Xiaoke KongNational Clinical Research Center for Endocrine and Metabolic Diseases, Metabolic Syndrome Research Center, Key Laboratory of Diabetes Immunology, Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Yiting TangDepartment of Physiology, Xiangya School of Basic Medical Sciences, Central South University, Changsha, 410000, China.
Bin ZhaoNational Clinical Research Center for Endocrine and Metabolic Diseases, Metabolic Syndrome Research Center, Key Laboratory of Diabetes Immunology, Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Fang FangInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, 17177, Sweden.
Jiaqi HuangNational Clinical Research Center for Endocrine and Metabolic Diseases, Metabolic Syndrome Research Center, Key Laboratory of Diabetes Immunology, Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China. jiaqi.huang@csu.edu.cn.
Ben LuDepartment of Critical Care Medicine and Hematology, The Third Xiangya Hospital, Central South University, Changsha, 410000, China. xybenlu@csu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypoxia is associated with systemic inflammation and oxidative stress, both of which contribute to sepsis development, yet whether impaired lung function is associated with a higher sepsis risk remains unclear. Leveraging data from 312,805 UK Biobank participants, we assessed baseline lung function as percentages of predicted forced vital capacity (FVC) and forced expiratory volume in one second (FEV

Indexed as

LungSepsisAgedCohort StudiesFemaleForced Expiratory VolumeHumansIncidenceMaleMiddle AgedProportional Hazards ModelsRespiratory Function TestsRisk FactorsUnited KingdomVital Capacitycohort studylung function impairmentsepsissepsis-related mortality

Identifiers

PMID41575701

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.