Evidence map›Paper›PMID 41575688›Full record

ArticleClinical and experimental nephrology2026

Association between early proteinuria reduction and kidney outcomes in Japanese patients with IgA nephropathy: The Japan Chronic Kidney Disease Database.

Yuichiro Yano, Hajime Nagasu, Hiroshi Kanegae, Seiji Itano, Masaomi Nangaku, Hitoshi Suzuki, Mizuki Ohashi, Hirokazu Okada, Yusuke Suzuki, Naoki Kashihara

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Clinical and experimental nephrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuichiro YanoDepartment of General Medicine, Faculty of Medicine, Juntendo University, 2-1-1, Hongo, Bunkyo-Ku, Tokyo, 113-8421, Japan. y.yano@juntendo.ac.jp.
Hajime NagasuDepartment of Nephrology and Hypertension, Kawasaki Medical School, Kurashiki, Okayama, Japan.
Hiroshi KanegaeGenki Plaza Medical Center for Health Care, Tokyo, Japan.
Seiji ItanoDepartment of Nephrology and Hypertension, Kawasaki Medical School, Kurashiki, Okayama, Japan.
Masaomi NangakuDivision of Nephrology and Endocrinology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
Hitoshi SuzukiDepartment of Nephrology, Faculty of Medicine, Juntendo University, Tokyo, Japan.
Mizuki OhashiDepartment of General Medicine, Faculty of Medicine, Juntendo University, 2-1-1, Hongo, Bunkyo-Ku, Tokyo, 113-8421, Japan.
Hirokazu OkadaDepartment of Nephrology, Faculty of Medicine, Saitama Medical University, Saitama, Japan.
Yusuke SuzukiDepartment of Nephrology, Faculty of Medicine, Juntendo University, Tokyo, Japan.
Naoki KashiharaDepartment of Nephrology and Hypertension, Kawasaki Medical School, Kurashiki, Okayama, Japan.

Funding

Japan Agency for Medical Research and Development JP19ek0210095Japan Agency for Medical Research and Development JP20ek0210135Japan Agency for Medical Research and Development JP20km0405210Japan Agency for Medical Research and Development JP23ek0109571Japan Agency for Medical Research and Development JP25ek0109812Ministry of Health, Labour and Welfare 19AC1002Ministry of Health, Labour and Welfare JPMH24FD1001
6 · The paper itself

Abstract

backgroundProteinuria reduction is an established surrogate endpoint for IgA nephropathy (IgAN) progression in international trials, but evidence in Japanese populations is scarce. We aimed to assess the association between early changes in proteinuria and long-term kidney outcomes in a large, real-world cohort of Japanese patients with IgAN.

methodsThis nationwide, multicenter cohort study utilized the Japan Chronic Kidney Disease Database (J-CKD-DB) data. We analyzed 1,039 IgAN patients (mean age 48.8 years; 46.0% women), categorized by dipstick proteinuria change at 9 ± 1 months from baseline: a reduction group (≥1-step improvement) and a non-reduction group (stable or worsened). The primary outcome was total eGFR slope; secondary was a composite kidney event (≥40% eGFR decline or eGFR < 15 mL/min/1.73 m

resultsThe mean baseline eGFR was 56.8 (±27.7) mL/min/1.73 m

conclusionsIn this large, real-world Japanese cohort, early dipstick proteinuria reduction was significantly associated with both a slower long-term eGFR decline and a lower risk of major kidney events. These findings may support the use of early proteinuria reduction as a surrogate endpoint for clinical trials and regulatory evaluation of IgA nephropathy in Japan.

Indexed as

Glomerular Filtration RateGlomerulonephritis, IGAKidneyProteinuriaAdultDatabases, FactualDisease ProgressionEast Asian PeopleFemaleHumansJapanMaleMiddle AgedRisk FactorsTime FactorsTreatment OutcomeEstimated glomerular filtration rateIgA nephropathyJ-CKD-DBProteinuria

Identifiers

PMID41575688

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.