Evidence map›Paper›PMID 41575628›Full record

ReviewCurrent osteoporosis reports2026

Transcriptomics in the Study of Bone and Cartilage.

Noah Fine, Jason S Rockel, Mohit Kapoor

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current osteoporosis reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Noah FineDivision of Orthopaedics, Osteoarthritis Research Program, Schroeder Arthritis Institute, University Health Network, Toronto, ON, Canada. Noah.Fine@uhn.ca.
Jason S RockelDivision of Orthopaedics, Osteoarthritis Research Program, Schroeder Arthritis Institute, University Health Network, Toronto, ON, Canada.
Mohit KapoorDivision of Orthopaedics, Osteoarthritis Research Program, Schroeder Arthritis Institute, University Health Network, Toronto, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewThis review article summarizes progress made using transcriptomics, in particular RNA-seq studies such as bulk, single cell (sc) and spatial sequencing results, in the study of bone and cartilage in the context of osteoarthritis (OA) and osteoporosis (OP) over the past two years. RECENT

findingsRecent advances in OA and OP research using advanced transcriptomics technologies have been crucial in the identification of cellular and molecular patterns of disease, facilitating a deeper knowledge of disease endotypes, mechanisms, and putative therapeutic targets. Increased use of public data repositories for hypothesis building and validation studies is an emerging theme in transcriptomics research, emphasizing the usefulness of growing transcriptomics databases to the research community. Due to unique challenges associated with bone and cartilage, it has been relatively difficult to deploy spatial sequencing in these tissues, however effective protocols for spatial sequencing have emerged, unlocking new potential for discovery.

Indexed as

Bone and BonesCartilageOsteoarthritisOsteoporosisTranscriptomeCartilage, ArticularGene Expression ProfilingHumansSpatial TranscriptomicsBoneCartilageMultiomicsTranscriptomics

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.