Evidence map›Paper›PMID 41575587›Full record

ReviewMikrochimica acta2026

Advances in optical and electrochemical aptasensors for tumor biomarker alpha-fetoprotein.

Zerun Zhang, Bin Wang, Pian Wu, Kermue Vasco Jarnda, Yuan Tian, Tianhan Kai, Cuimei Chen, Ping Ding

Abstract readReview
PubMed Publisher
In one paragraph

Review in Mikrochimica acta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zerun ZhangXiangya School of Public Health, Central South University, Changsha, Hunan, 410078, China.
Bin WangXiangya School of Public Health, Central South University, Changsha, Hunan, 410078, China.
Pian WuXiangya School of Public Health, Central South University, Changsha, Hunan, 410078, China.
Kermue Vasco JarndaXiangya School of Public Health, Central South University, Changsha, Hunan, 410078, China.
Yuan TianXiangya School of Public Health, Central South University, Changsha, Hunan, 410078, China.
Tianhan KaiXiangya School of Public Health, Central South University, Changsha, Hunan, 410078, China.
Cuimei ChenSchool of Public Health, XiangNan University, Chenzhou, Hunan, China. cmc_xnxy66@163.com.
Ping DingXiangya School of Public Health, Central South University, Changsha, Hunan, 410078, China. Pingshui@csu.edu.cn.

Funding

the National Natural Science Foundation of China 82373635the Natural Science Foundation of Changsha kq2402240the Natural Science Foundation of Hunan 2025JJ60624the Science and Technology Innovation Program of Hunan Province 2022RC1206
6 · The paper itself

Abstract

Alpha-fetoprotein (AFP) is a critical tumor biomarker associated with various diseases, and its accurate determination is very important for clinical detection. However, the conventional techniques for detecting AFP have drawbacks such as complex sample pretreatment procedures, complicated and time-consuming operations, reliance on expensive and bulky instruments, and the need for skilled professionals, thus limiting their applications. The emergence of aptamers provides a novel and unique probe for establishment of aptasensors, effectively avoiding the aforementioned shortcomings. As a result, the application of aptamers for AFP detection has garnered increasing attention and became one of the research hotspots in recent years. In this review, the progress of aptamer selection against AFP is presented initially. Subsequently, we systematically summarize the latest advancements and trends in optical and electrochemical aptasensors for AFP detection, focusing on known AFP aptamer sequences and methods that use aptamers, such as fluorescence, surface-enhanced Raman scattering (SERS), chemiluminescence (CL), and photoelectrochemistry (PEC). In addition, challenges and future directions in this field are discussed to provide insights for the development of efficient and accurate AFP detection technologies.

Indexed as

alpha-FetoproteinsAptamers, NucleotideBiomarkers, TumorBiosensing TechniquesElectrochemical TechniquesHumansSpectrum Analysis, Ramanalpha-FetoproteinsAptamers, NucleotideBiomarkers, TumorAlpha-fetoproteinAptamerBiosensorOptical and electrochemical aptasensorsTumor biomarker

Identifiers

PMID41575587

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.