Evidence map›Paper›PMID 41575524›Full record

ArticlePediatric nephrology (Berlin, Germany)2026

Plasma-saliva correlations for total and unbound mycophenolic acid and its glucuronide in children with nephrotic syndrome.

Klaudia Babacz, Anna Benedyk, Jacek Zachwieja, Danuta Ostalska-Nowicka, Joanna Sobiak

Abstract read
PubMed Publisher
In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Klaudia BabaczDepartment of Physical Pharmacy and Pharmacokinetics, Poznan University of Medical Sciences, Poznań, Poland.
Anna BenedykDepartment of Pediatric Nephrology and Hypertension, Poznan University of Medical Sciences, Poznań, Poland.
Jacek ZachwiejaDepartment of Pediatric Nephrology and Hypertension, Poznan University of Medical Sciences, Poznań, Poland.
Danuta Ostalska-NowickaDepartment of Pediatric Nephrology and Hypertension, Poznan University of Medical Sciences, Poznań, Poland.
Joanna SobiakDepartment of Physical Pharmacy and Pharmacokinetics, Poznan University of Medical Sciences, Poznań, Poland. jsobiak@ump.edu.pl.ORCID http://orcid.org/0000-0002-2764-1575

Funding

Narodowe Centrum Nauki 2021/05/X/NZ7/00353
6 · The paper itself

Abstract

backgroundFor mycophenolic acid (MPA), therapeutic drug monitoring (TDM) is recommended due to its complex pharmacokinetics. A non-invasive TDM approach using saliva is promising due to its simplicity and minimal invasiveness. This study investigated the relationship between MPA and its glucuronide metabolite (MPAG) levels in saliva and plasma in children with nephrotic syndrome (NS).

methodsSalivary MPA (sMPA) and MPAG (sMPAG), as well as total MPA (tMPA), total MPAG (tMPAG), and free MPA (fMPA) in plasma were determined for 23 children aged 4-17 years with NS. All children were treated with mycophenolate mofetil twice daily at the same morning and evening doses based on body surface area. Saliva and blood samples were collected before the next dose (C

resultsThe concentration-time profiles showed a similar course for tMPA, sMPA, and fMPA, with the highest variability observed for sMPA. The mean C

conclusionsSaliva may represent a promising matrix for MPA TDM in children with NS, as sMPA and sMPAG generally reflected plasma levels. However, salivary pharmacokinetics exhibited considerable variability, and C

Indexed as

Drug MonitoringGlucuronidesImmunosuppressive AgentsMycophenolic AcidNephrotic SyndromeSalivaAdolescentChildChild, PreschoolFemaleHumansMaleGlucuronidesImmunosuppressive AgentsMycophenolic Acidmycophenolic acid glucuronideMycophenolate mofetilNephrotic syndromePediatric patientsPlasmaSalivaTherapeutic drug monitoring

Identifiers

PMID41575524

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.