ArticlePsychopharmacology2026
Effects of methamphetamine on signalled probability in rats using concurrent chains.
Article in Psychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
2 authors.
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Abstract
Pigeons show a suboptimal choice for probabilistic reinforcement in the presence of informative stimuli, which has been proposed as an animal model of gambling. However, this behaviour has been difficult to replicate in rats. In our study, rats responded on alternatives that provided 50% or 100% reinforcement with half of the sessions reliably signalled and half un-signalled. Contrary to expectation, rats preferred the optimal alternative to a greater extent in the signalled sessions compared to the un-signalled sessions. Acute methamphetamine increased preference for the 50% alternative exclusively in signalled sessions. These results suggest that rats, unlike pigeons, are able to use the information provided by the stimulus correlated with non-reinforcement to shift preference away from the suboptimal alternative, and that the influence of methamphetamine on rats' probabilistic choice is context dependent.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.