Discordant ADC and DWI signal evolution in hyperacute stroke: implications for early imaging interpretation.

Anna Szőcs, Máté Magyar, Pál Maurovich-Horvat, Péter Barsi

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Article in Neuroradiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Anna Szőcs *Medical Imaging Centre, Neuroradiology Department, Semmelweis University, Budapest, Hungary. annaszocs@gmail.com.

Máté Magyar *Medical Imaging Centre, Neuroradiology Department, Semmelweis University, Budapest, Hungary.

Pál Maurovich-HorvatMedical Imaging Centre, Semmelweis University, Budapest, Hungary.

Péter BarsiMedical Imaging Centre, Neuroradiology Department, Semmelweis University, Budapest, Hungary.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Here we report the first human observation of an imaging pattern in early hyperacute ischemic stroke, in which restricted diffusion is detectable on ADC maps before it becomes appreciable on DWI. The pattern—an ADC/DWI mismatch—was incidentally captured in a thalamic infarct during MRI obtained after a transient ischemic attack in a different vascular territory, enabling observation at an early hyperacute stage. Quantitative measurements at three time points demonstrated falling relative ADC and slower-rising relative DWI signal, aligning with thresholds for visual detectability. Although anticipated by animal data, this dissociation has not, to our knowledge, been documented in humans. Recognition of this putative earliest stage of ischemia may refine stroke diagnosis and inform MRI acquisition and interpretation protocols.

Indexed as

Diffusion Magnetic Resonance ImagingIschemic StrokeStrokeEarly DiagnosisHumansImage Interpretation, Computer-AssistedMaleADC/DWI mismatchDiffusion MRIHyperacute strokeUltra-early stroke imaging

Identifiers

PMID41575498

DOI10.1007/s00234-026-03910-3

PMCPMC13099746

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.