Evidence map›Paper›PMID 41575445›Full record

ArticleTranslational vision science & technology2026

Impact of Age-Related Changes in Lens Shape on the Increased Risk of Posterior Capsule Opacification Observed in Pediatric Cataract Patients.

Samira Izuagbe, Tejas Alankar, Katherine Zoller, Farjana F Bhuiyan, Precious Obafemi, Feabie Mendiaz, Bhavya Vaish, Melinda K Duncan, Hongli Wu, Liping Tang

Abstract read
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In one paragraph

Article in Translational vision science & technology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Samira IzuagbeDepartment of Bioengineering, College of Engineering, University of Texas at Arlington, Arlington, TX, USA.
Tejas AlankarDepartment of Bioengineering, College of Engineering, University of Texas at Arlington, Arlington, TX, USA.
Katherine ZollerDepartment of Bioengineering, College of Engineering, University of Texas at Arlington, Arlington, TX, USA.
Farjana F BhuiyanDepartment of Bioengineering, College of Engineering, University of Texas at Arlington, Arlington, TX, USA.
Precious ObafemiDepartment of Bioengineering, College of Engineering, University of Texas at Arlington, Arlington, TX, USA.
Feabie MendiazDepartment of Bioengineering, College of Engineering, University of Texas at Arlington, Arlington, TX, USA.
Bhavya VaishDepartment of Bioengineering, College of Engineering, University of Texas at Arlington, Arlington, TX, USA.
Melinda K DuncanDepartment of Biological Sciences, University of Delaware, Newark, DE, USA.
Hongli WuDepartment of Pharmaceutical Sciences, College of Pharmacy, North Texas Eye Research Institute, University of North Texas Health Science Center, Fort Worth, TX, USA.
Liping TangDepartment of Bioengineering, College of Engineering, University of Texas at Arlington, Arlington, TX, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Posterior capsule opacification (PCO) rates are higher in young cataract patients compared to adults, a phenomenon attributed to a higher proliferative potential of young lens epithelial cells (LECs). This study investigates the hypothesis that implanting standard (adult-sized) intraocular lenses (IOLs) in pediatric patients, whose lenses are smaller and more spherical, results in a low contact between the IOL and the posterior lens capsule (PLC), thus contributing to elevated pediatric PCO rates. Methods: Simulated PLCs (sPLC) modeling the size and curvatures of human lenses of eight-year-old (8y-sPLC), 25-year-old (25y-sPLC), and 65-year-old (65y-sPLC) individuals were fabricated. The physical interactions between standard IOL and the sPLCs were quantified using optical coherence tomography (OCT) and adhesion force testing. Furthermore, the influence of age-dependent lens shape on young and adult primary mouse LEC responses (infiltration, proliferation, and epithelial-mesenchymal transdifferentiation [EMT]) was investigated. Results: The 8y-sPLC exhibited the least contact with IOLs, followed by 25y-sPLC and 65y-sPLC. Consequently, despite an inherent difference in cell activity, both young and adult LECs exhibited higher responses at the IOL-8y-sPLC interface compared to the 25y- and 65y-sPLC interfaces. Regression analyses confirmed that low IOL-PLC contact, observed only with 8y-sPLC, accompanied by higher cell responses from both young and adult LECs. Conclusions: The findings suggest that the mismatch in size and curvature between pediatric PLCs and standard IOLs may be a key factor contributing to higher PCO rates observed in young cataract patients. Translational Relevance: Our findings provide foundational knowledge for designing age-specific IOLs that optimize IOL-PLC contact, potentially reducing pediatric PCO incidence.

Indexed as

AgingCapsule OpacificationCataractLens, CrystallineLenses, IntraocularPosterior Capsule of the LensAdultAgedAge FactorsAnimalsChildEpithelial CellsHumansLens Implantation, IntraocularMaleMice

Identifiers

PMID41575445
PMCPMC12854235

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.