ArticleACS macro letters2026
Injectable Bi-layered Cryogel Scaffolds for Targeted Adhesion to Tissues.
Article in ACS macro letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
We present a simple strategy to fabricate injectable bi-layered hyaluronic acid cryogel scaffolds for use in biomedical applications. Specifically, bi-layered cryogel scaffolds were formed via the sequential freezing, layering, and photo-cross-linking of individual macromer solutions, introducing defined interfaces without compromising scaffold porosity and mechanical integrity. We leveraged this fabrication technique to create an easily deployable Janus patch that is non-adhesive on one side and adhesive to tissues (via electrostatic and covalent bonding) on the other side. This is of particular interest in the development of cardiac patches that should adhere to the epicardial surface of the heart but not to other tissues. Once applied with the adhesive side in contact with the heart muscle, the patch remained adhered for over 2 weeks ex vivo, whereas the non-adhesive side resisted tissue adhesion. As a further proof-of-concept, the scaffold was injected into the fluid-filled pericardial space of explanted hearts and showed directional adhesion.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.