ArticleJournal of gynecologic oncology2026
Prognostic value and adjuvant treatment outcomes for the use of the JGOG prognostic model in early-stage intermediate-risk cervical cancer: a Korean Gynecologic Oncology Group study (KGOG 1028).
Article in Journal of gynecologic oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Abstract
objectiveThe aim of this study was to validate a new Japanese risk grouping in the Korean population and to identify the group benefit from adjuvant treatment.
methodsA total of 561 patients with stage IB cervical cancer who underwent radical hysterectomy with lymphadenectomy from 2000 to 2008 across 9 Korean Gynecologic Oncology Group-affiliated institutions were included in this study. Patients had at least one intermediate-risk factor: lymphovascular space invasion, outer one-third of the deep cervical stromal invasion, or a tumor 4 cm or larger. Disease-free survival (DFS) was analyzed based on adjuvant therapies: no treatment, radiation therapy, concurrent chemoradiation therapy or systemic chemotherapy.
resultsPatients were classified into 3 groups based on their histologically-incorporated intermediate risk factors. Group 1 included patients with limited risk factors (n=385, 68.6%), group 2 (n=106, 18.9%), and group 3 (n=70, 12.5%) had increasing risk. DFS differed across groups (group 1 vs. group 2, p=0.048; group 2 vs. group 3, p=0.030). Group 1 showed no DFS benefit from adjuvant treatment, while in groups 2 and 3, receiving radiation therapy improved DFS (group 2: adjusted hazard ratio [aHR]=0.09; 95% confidence interval [CI]=0.01-0.80; p=0.031 and group 3: aHR=0.21; 95% CI=0.04-1.08; p=0.047). In group 3, receiving concurrent chemotherapy treatment did not significantly affect DFS compared to radiation alone (aHR=0.84; 95% CI=0.11-6.30; p=0.861).
conclusionThis study revealed the prognostic value of histology-incorporated intermediate-risk stratification for early-stage cervical cancer in the Korean population. Unlike the results seen in Japanese populations, adjuvant treatment benefited higher-risk patients in terms of DFS.
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