Evidence map›Paper›PMID 41575075›Full record

ArticleProtein science : a publication of the Protein Society2026

The soluble state of the HIV-1 Vpu protein forms a complex with Ca

Olamide Ishola, Md Majharul Islam, Elaheh Hadadianpour, Peter P Borbat, Adeyemi Ogunbowale, Juan C R Amador, Elka R Georgieva

Abstract read
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In one paragraph

Article in Protein science : a publication of the Protein Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. The soluble state of the HIV-1 Vpu protein forms a complex with CaProtein science : a publication of the Protein Society · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Olamide IsholaDepartment of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas, USA.
Md Majharul IslamDepartment of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas, USA.
Elaheh HadadianpourDepartment of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas, USA.
Peter P BorbatDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, New York, USA.
Adeyemi OgunbowaleDepartment of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas, USA.
Juan C R AmadorDepartment of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas, USA.
Elka R GeorgievaDepartment of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas, USA.ORCID https://orcid.org/0000-0001-9980-5260

Funding

National Biomedical Resource for Electron-Spin Resonance Spectroscopy (ACERT)R24GM146107 · NIGMS · CORNELL UNIVERSITY · PI BRIAN R CRANE, Jack H Freed · 2022 to 2026
$6.4M
Gilead's Research Scholars in HIVNIGMS NIH HHS R24 GM146107NIH HHS 1R24GM146107
6 · The paper itself

Abstract

The HIV-1 Vpu membrane protein is crucial to the virus lifecycle. Our recent studies revealed soluble Vpu oligomers, prompting further investigation into their interactions with cellular proteins. Notably, Vpu may form a complex with calmodulin (CaM) due to its putative CaM-binding motif; however, experimental proof of this association is unavailable. Here, we present definitive experimental evidence that the soluble Vpu complex interacts in vitro with calcium-bound CaM (Ca

Indexed as

CalciumCalmodulinHIV-1Human Immunodeficiency Virus ProteinsViral Regulatory and Accessory ProteinsElectron Spin Resonance SpectroscopyHumansProtein BindingSolubilityViroporin ProteinsCalciumCalmodulinHuman Immunodeficiency Virus ProteinsViral Regulatory and Accessory ProteinsViroporin Proteinsvpu protein, Human immunodeficiency virus 1DEER spectroscopy on protein–protein complexesFRET in protein–protein interactionsprotein conformational changessoluble HIV‐1 Vpu proteinsoluble Vpu–calmodulin interaction

Identifiers

PMID41575075
PMCPMC12828991

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.