Evidence map›Paper›PMID 41574972›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2026

Real-Time In Vivo Detection of Nanocarrier Number and Velocity in the Cerebrovasculature Using Hot Band Absorption.

Xiaojin Wang, Mikkel B Liisberg, Vanessa Rück, Sagar Pande, Georgia L Nolt, Lan Li, Qianye Yin, Brock T Harvey, Julia Nagel, Xu Fu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xiaojin WangDepartment of Chemistry, University of Kentucky, Lexington, Kentucky, USA.ORCID https://orcid.org/0000-0001-8793-3708
Mikkel B LiisbergNanoscience Center & Department of Chemistry, University of Copenhagen, Copenhagen, Denmark.ORCID https://orcid.org/0000-0001-7623-5453
Vanessa RückNanoscience Center & Department of Chemistry, University of Copenhagen, Copenhagen, Denmark.
Sagar PandeDepartment of Chemistry, University of Kentucky, Lexington, Kentucky, USA.
Georgia L NoltDepartment of Physiology & Sanders Brown Center On Aging, University of Kentucky, Lexington, Kentucky, USA.
Lan LiDepartment of Chemistry, University of Kentucky, Lexington, Kentucky, USA.
Qianye YinDepartment of Chemistry, University of Kentucky, Lexington, Kentucky, USA.
Brock T HarveyDepartment of Chemistry, University of Kentucky, Lexington, Kentucky, USA.
Julia NagelMarkey Cancer Center, College of Medicine, University of Kentucky, Lexington, Kentucky, USA.
Xu FuLight Microscopy Core, University of Kentucky, Lexington, Kentucky, USA.
Lance A JohnsonDepartment of Physiology & Sanders Brown Center On Aging, University of Kentucky, Lexington, Kentucky, USA.
Tom VoschNanoscience Center & Department of Chemistry, University of Copenhagen, Copenhagen, Denmark.ORCID https://orcid.org/0000-0001-5435-2181
Christopher I RichardsDepartment of Chemistry, University of Kentucky, Lexington, Kentucky, USA.ORCID https://orcid.org/0000-0003-0019-1989

Funding

Oncology Research Training for Surgeon-ScientistsT32CA160003 · NCI · UNIVERSITY OF KENTUCKY · PI Bernard Mark Evers, Pamela Carmen Hull · 2011 to 2026
$3.2M
Role of small molecule interactions and multiprotein assemblies in CYP1B1 disease-associated function and dysfunctionR01GM138882 · NIGMS · UNIVERSITY OF KENTUCKY · PI GLAZER, EDITH C, HEIDARY, DAVID · 2020 to 2024
$1.9M
Ex vivo single molecule tools to analyze membrane receptor dynamicsR01GM138837 · NIGMS · UNIVERSITY OF KENTUCKY · PI RICHARDS, CHRISTOPHER I · 2021 to 2024
$1.2M
NCI NIH HHS T32 CA160003NIGMS NIH HHS R01 GM138837NIGMS NIH HHS R01 GM138882NIH HHS GM138837NIH HHS GM138882Novo Nordisk Foundation NNF20OC0064207Novo Nordisk Foundation NNF22OC0073734
6 · The paper itself

Abstract

Nanocarriers play a critical role in the transport and targeted delivery of therapeutic agents. However, real-time in vivo observation of individual nanocarriers in the circulatory system is challenging due to the need for high spatiotemporal resolution and sensitivity. Here, DNA-stabilized silver nanoclusters (DNA640), which exhibit anti-Stokes fluorescence upon hot-band absorption (HBA), are loaded into cationic mesoporous silica nanoparticles (CMSN) and coated with liposomes. These constructs (DNA640-CMSN-liposome) exhibit improved resistance to chloride ions (Cl

Indexed as

Cerebrovascular CirculationDrug CarriersNanoparticlesAnimalsDNALiposomesSilicon DioxideSilverSpectrometry, FluorescenceDNADrug CarriersLiposomesSilicon DioxideSilverDNA‐stabilized silver nanoclustersfluorescence correlation spectroscopyhot‐band absorptionin vivonanocarriersNIR fluorescence

Identifiers

PMID41574972
PMCPMC12991056

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.