Evidence map›Paper›PMID 41574892›Full record

ArticleActa paediatrica (Oslo, Norway : 1992)2026

Age Does Not Affect Respiratory Characteristics in Children With Prader-Willi Syndrome Before and After Growth Hormone Therapy.

Michelle Ip, Sze Lut Cheng, Okkes R Patoglu, Georgina Plunkett, Lauren C Nisbet, Gillian M Nixon, Margot J Davey, Rosemary S C Horne

Abstract read
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In one paragraph

Article in Acta paediatrica (Oslo, Norway : 1992), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Michelle IpDepartment of Paediatrics, Monash University, Melbourne, Australia.
Sze Lut ChengDepartment of Paediatrics, Monash University, Melbourne, Australia.
Okkes R PatogluDepartment of Paediatrics, Monash University, Melbourne, Australia.
Georgina PlunkettDepartment of Paediatrics, Monash University, Melbourne, Australia.ORCID 0009-0002-2351-6336
Lauren C NisbetDepartment of Paediatrics, Monash University, Melbourne, Australia.
Gillian M NixonDepartment of Paediatrics, Monash University, Melbourne, Australia.
Margot J DaveyDepartment of Paediatrics, Monash University, Melbourne, Australia.
Rosemary S C HorneDepartment of Paediatrics, Monash University, Melbourne, Australia.

Funding

National Health and Medical Research Council 1195453
6 · The paper itself

Abstract

aimChildren with Prader-Willi syndrome (PWS) are at increased risk of both central (CSA) and obstructive sleep apnoea (OSA). Studies examining the effects of growth hormone have focused on older children; however, therapy is often initiated before the age of 2 years. We determined the effects of age on (1) the number of children diagnosed with OSA and CSA; (2) the sleep and respiratory characteristics and (3) the effects of growth hormone on OSA and CSA.

methodsRetrospective review of children with PWS who underwent polysomnography pre- and post-growth hormone between January 2011 and June 2024.

resultsFifty-six children (35 < 2 years; 21 ≥ 2 years) pre-growth hormone; 28 children < 2 years and 15 children ≥ 2 years after growth hormone. Pre-growth hormone, children ≥ 2 years had more severe OSA than children < 2 years (p < 0.05). There was no difference between age groups for CSA. Post-growth hormone, 21% of children < 2 years and 20% of children ≥ 2 years developed OSA. CSA resolved post-growth hormone in 21% of children < 2 years and 6% of children ≥ 2 years, whilst CSA developed in 11% and 13%, respectively.

conclusionOur study highlights that very young children do not appear to be at higher risk of development of OSA or CSA when treated with growth hormone.

Indexed as

Human Growth HormonePrader-Willi SyndromeSleep Apnea, CentralSleep Apnea, ObstructiveAge FactorsChildChild, PreschoolFemaleHumansInfantMalePolysomnographyRetrospective StudiesHuman Growth Hormonecentral sleep apnoeagrowth hormoneobstructive sleep apnoeaPrader‐Willi syndromesleep

Identifiers

PMID41574892
PMCPMC13063354

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.