Evidence map›Paper›PMID 41574838›Full record

ArticleJournal of medicinal chemistry2026

Development of Novel Small-Molecule Targeting SCN1A-Associated Severe Myoclonic Epilepsy of Infancy.

Dong Gun Kim, Kyu-Seok Hwang, Se Hwan Ahn, Seong Soon Kim, Yuji Son, Sung Bum Park, Won Hoon Jung, Dae-Seop Shin, Sung Hee Cho, Byeong Wook Choi and 11 more

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Dong Gun KimDepartment of Chemistry, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea.
Kyu-Seok HwangTherapeutics & Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea.ORCID 0000-0003-4606-1354
Se Hwan AhnDepartment of Chemistry, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea.
Seong Soon KimTherapeutics & Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea.ORCID 0000-0002-4762-8693
Yuji SonTherapeutics & Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea.
Sung Bum ParkTherapeutics & Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea.
Won Hoon JungTherapeutics & Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea.
Dae-Seop ShinTherapeutics & Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea.
Sung Hee ChoTherapeutics & Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea.
Byeong Wook ChoiDepartment of Chemistry, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea.ORCID 0000-0003-1989-131X
Pyeongkeun KimDepartment of Chemistry, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea.ORCID 0009-0004-1203-2533
Yerim HeoDepartment of Chemistry, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea.
Minhee KimTherapeutics & Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea.
Jung Yoon YangTherapeutics & Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea.
Kyeong-Ryoon LeeDepartment of Medical Chemistry and Pharmacology, University of Science & Technology, Daejeon 34113, Republic of Korea.ORCID 0000-0003-2175-8876
Hyang-Ae LeeCenter for Biomimetic Research, Korea Institute of Toxicology, Daejeon 34114, Republic of Korea.ORCID 0000-0002-0036-4555
Jihun KimDivision of Pediatric Neurology, Department of Pediatrics, Severance Children's Hospital, Yonsei University College of Medicine, Epilepsy Research Institute, Seoul 03722, Republic of Korea.
Hoon-Chul KangDivision of Pediatric Neurology, Department of Pediatrics, Severance Children's Hospital, Yonsei University College of Medicine, Epilepsy Research Institute, Seoul 03722, Republic of Korea.
Ki Young KimTherapeutics & Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea.
Myung Ae BaeTherapeutics & Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea.
Jin Hee AhnDepartment of Chemistry, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea.ORCID 0000-0002-6957-6062

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe myoclonic epilepsy of infancy (SMEI, Dravet syndrome), which is mainly caused by the

Indexed as

AnticonvulsantsEpilepsies, MyoclonicAnimalsHumansMiceNAV1.1 Voltage-Gated Sodium ChannelStructure-Activity RelationshipZebrafishAnticonvulsantsNAV1.1 Voltage-Gated Sodium ChannelSCN1A protein, human

Identifiers

PMID41574838
PMCPMC12910655

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.