Evidence map›Paper›PMID 41574713›Full record

Trial reportHead & neck2026

Short-Term Outcomes of Advanced Pneumatic Compression Device Versus Usual Care Therapy for Head and Neck Cancer-Related Lymphedema: A Multi-Site Randomized Clinical Trial.

Barbara A Murphy, Derek K Smith, Cristina M Kline-Quiroz, Katrina M Jensen, Ammar W Sukari, Mihir K Bhayani, Vikas Mehta, Harry Quon, Jennifer L Shah, Christopher D Willey and 4 more

Registry-linked trialAbstract readRandomized Controlled TrialMulticenter StudyComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Head & neck, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04797390 (A Randomized Trial of an Advanced Pneumatic Compression Device vs. Usual Care for Head and Neck Lymphedema), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04797390 nacompletednot on this map

A Randomized Trial of an Advanced Pneumatic Compression Device vs. Usual Care for Head and Neck Lymphedema

TypeinterventionalSponsorTactile MedicalRan2021 to 2024Enrolled236ConditionsLymphedema, Lymphedema of Face, Lymphedema, Secondary, Lymphedema Due to RadiationArmsAdvanced Pneumatic Compression Device (APCD), Usual Care
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Barbara A MurphyDivision of Hematology and Oncology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Derek K SmithDivision of Biostatistics and Computational Biology, University of Iowa College of Dentistry, Iowa City, Iowa, USA.
Cristina M Kline-QuirozDepartment of Physical Medicine and Rehabilitation, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Katrina M JensenAdvanced Head & Neck Rehabilitation Center of Texas, Fort Worth, Texas, USA.
Ammar W SukariDepartment of Otolaryngology-Head and Neck Surgery, Karmanos Cancer Institute, Detroit, Michigan, USA.
Mihir K BhayaniDepartment of Otolaryngology-Head and Neck Surgery, Rush University Medical Center, Chicago, Illinois, USA.
Vikas MehtaDepartment of Otorhinolaryngology-Head and Neck Surgery, Montefiore Medical Center, Bronx, New York, USA.
Harry QuonDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins Medical Center, Baltimore, Maryland, USA.
Jennifer L ShahDepartment of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, USA.
Christopher D WilleyDepartment of Radiation Oncology, University of Alabama Birmingham, Birmingham, Alabama, USA.
Neal E DunlapDepartment of Radiation Oncology, University of Louisville Research Foundation Inc., University of Louisville, Louisville, Kentucky, USA.
Hoon K LeeRadiation Oncology, Richmond University Medical Center, Staten Island, New York, USA.
Joseph M AulinoDepartment of Radiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Sheila H RidnerSchool of Nursing, Vanderbilt University, Nashville, Tennessee, USA.

Funding

Tactile Medical
6 · The paper itself

Abstract

backgroundTwo-month outcomes of advanced pneumatic compression device (APCD) and usual care (UC) in Head and Neck Cancer survivors with previously untreated lymphedema were compared.

methodsParticipants in this multisite, randomized clinical trial were randomized to APCD or UC. The primary endpoint was severity of lymphedema symptoms. Secondary endpoints were anatomical lymphedema changes, biopsychosocial outcomes, and barriers to care.

resultsTwo hundred thirty-six participants were enrolled (119 APCD, 117 UC). Analysis was intention-to-treat. Lymphedema-associated symptom burden measured using the VHNSS and LSIDS was improved to a similar degree in both groups. APCD demonstrated a statistically significant improvement in external soft tissue swelling assessed by digital photography. No difference in CT imaging measures of lymphedema was noted. UC participants experienced barriers to care.

conclusionsAPCD is an effective treatment for lymphedema in HNCS. The APCD addresses clinically significant barriers to therapist guided treatment. A hybrid approach may be complementary and optimize patient outcomes.

trial registrationNCT04797390.

Indexed as

Head and Neck NeoplasmsIntermittent Pneumatic Compression DevicesLymphedemaAdultAgedFemaleHumansMaleMiddle AgedTreatment Outcomeadvanced pneumatic compression devicehead and necklymphedemashort‐term outcomesusual care lymphedema therapy

Identifiers

PMID41574713
PMCPMC12972646

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.