Evidence map›Paper›PMID 41574701›Full record

ReviewInternational journal of molecular medicine2026

Pablo Michael Navarro-Rodríguez, Ramón Francisco Bajeca-Serrano, Francisco Javier Turrubiates-Hernández, Hazael Ramiro Ceja-Gálvez, Jorge Hernández-Bello, Cristian Oswaldo Hernández-Ramírez, Saúl Ramírez-de Los Santos, José Francisco Muñoz-Valle

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pablo Michael Navarro-Rodríguez *Department of Molecular Biology and Genomics, University Center of Health Sciences, University of Guadalajara, Guadalajara, Jalisco 44340, Mexico.
Ramón Francisco Bajeca-Serrano *Department of Clinical Medicine, Institute of Research in Biomedical Sciences, University Center of Health Sciences, University of Guadalajara, Guadalajara, Jalisco 44340, Mexico.
Francisco Javier Turrubiates-HernándezDepartment of Clinical Medicine, Institute of Research in Biomedical Sciences, University Center of Health Sciences, University of Guadalajara, Guadalajara, Jalisco 44340, Mexico.
Hazael Ramiro Ceja-GálvezDepartment of Clinical Medicine, Institute of Research in Biomedical Sciences, University Center of Health Sciences, University of Guadalajara, Guadalajara, Jalisco 44340, Mexico.
Jorge Hernández-BelloDepartment of Clinical Medicine, Institute of Research in Biomedical Sciences, University Center of Health Sciences, University of Guadalajara, Guadalajara, Jalisco 44340, Mexico.
Cristian Oswaldo Hernández-RamírezDepartment of Clinical Medicine, Institute of Research in Biomedical Sciences, University Center of Health Sciences, University of Guadalajara, Guadalajara, Jalisco 44340, Mexico.
Saúl Ramírez-de Los SantosDepartment of Clinical Medicine, Institute of Research in Biomedical Sciences, University Center of Health Sciences, University of Guadalajara, Guadalajara, Jalisco 44340, Mexico.
José Francisco Muñoz-ValleDepartment of Clinical Medicine, Institute of Research in Biomedical Sciences, University Center of Health Sciences, University of Guadalajara, Guadalajara, Jalisco 44340, Mexico.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The one‑carbon metabolism pathway, regulated by the methylenetetrahydrofolate reductase (MTHFR) enzyme, represents a key nexus where genetic predisposition and nutrient status converge to shape the epigenetic landscape of autoimmune diseases. The objective of the present review is to synthesize evidence of how the

Indexed as

Autoimmune DiseasesEpigenesis, GeneticFolic AcidMethylenetetrahydrofolate Reductase (NADPH2)AnimalsDNA MethylationHumansFolic AcidMethylenetetrahydrofolate Reductase (NADPH2)MTHFR protein, humanautoimmune diseasesDNA methylationepigenomicsfolateMTHFRS‑adenosylmethionine

Identifiers

PMID41574701
PMCPMC12851853

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.