Evidence map›Paper›PMID 41574642›Full record

ArticleMolecular genetics & genomic medicine2026

A Novel A-Kinase-Anchoring Protein 9 Variant in Premature Coronary Artery Disease: A Case Series.

Yuemiao Jiao, Minxian Wang, Guifen Qiang, Li Zhao, Ziwei Xi, Yue Yu, Chengqian Yin, Guangyuan Song

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular genetics & genomic medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Yuemiao JiaoDepartment of Interventional Center of Valvular Heart Disease, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Minxian WangNational Genomics Data Center, China National Center for Bioinformation, Beijing, China.
Guifen QiangState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College and Beijing Key Laboratory of Drug Target and Screening Research, Beijing, China.
Li ZhaoSchool of Sport Science, Beijing Key Laboratory of Sports Function Assessment and Technical Analysis, Beijing Sport University, Beijing, China.
Ziwei XiDepartment of Interventional Center of Valvular Heart Disease, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Yue YuDepartment of Interventional Center of Valvular Heart Disease, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0009-0004-5005-3861
Chengqian YinDepartment of Interventional Center of Valvular Heart Disease, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Guangyuan SongDepartment of Interventional Center of Valvular Heart Disease, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

Funding

National Key Research and Development Program of China 2022YFC3600201
6 · The paper itself

Abstract

backgroundFamilial premature coronary artery disease (CAD) is often associated with genetic variants. This study investigated potential causal variants in a Chinese pedigree with premature CAD.

methodsIn total, nine family members were included in the study (six CAD patients and three unaffected controls). Whole-exome sequencing (WES) was performed on six family members (including four patients and two unaffected controls), and the candidate variant was further validated by Sanger sequencing in four individuals.

resultsA strong linkage between c.6406C>G (p.Gln2136Glu; NM_005751.5) in AKAP9 (A-KINASE ANCHOR PROTEIN 9; OMIM 604001) and premature CAD was detected in the pedigree. Functional analysis revealed that the c.6406C>G variant in AKAP9 decreased the interaction between AKAP9 and PRKAR2A. This association was first detected in premature CAD patients.

conclusionsOur findings indicate that c.6406C>G in the AKAP9 gene could be a causal variant for premature CAD in the Chinese population.

Indexed as

A Kinase Anchor ProteinsCoronary Artery DiseaseAdultAMP-Activated Protein KinasesCytoskeletal ProteinsFemaleHumansMaleMiddle AgedPedigreeAKAP9 protein, humanA Kinase Anchor ProteinsAMP-Activated Protein KinasesCytoskeletal ProteinsPRKAG2 protein, humanAKAP9familial premature coronary artery diseasewhole‐exome sequencing

Identifiers

PMID41574642
PMCPMC12828268

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.