Evidence map›Paper›PMID 41574574›Full record

ArticleeLife2026

Computational modelling identifies key determinants of subregion-specific dopamine dynamics in the striatum.

Aske Ejdrup, Jakob Kisbye Dreyer, Matthew D Lycas, Søren H Jørgensen, Trevor W Robbins, Jeffrey Dalley, Freja Herborg, Ulrik Gether

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Aske Ejdrup *Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID https://orcid.org/0000-0002-4235-7310
Jakob Kisbye DreyerDepartment of Bioinformatics, H Lundbeck A/S, Valby, Denmark.
Matthew D LycasDepartment of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Søren H JørgensenDepartment of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Trevor W RobbinsBehavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, United Kingdom.ORCID https://orcid.org/0000-0003-0642-5977
Jeffrey DalleyBehavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, United Kingdom.
Freja Herborg *Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID https://orcid.org/0000-0002-0159-4598
Ulrik Gether *Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID https://orcid.org/0000-0002-0020-3807

Funding

Lundbeck Foundation R181-2014-3090Lundbeck Foundation R266-2017-4331Lundbeck Foundation R276-2018-792Lundbeck Foundation R303-2018-3540Lundbeck Foundation R359-2020-2301The Novo Nordisk Foundation NNF24OC0088870
6 · The paper itself

Abstract

Striatal dopamine (DA) release regulates reward-related learning and motivation and is believed to consist of a short-lived

Indexed as

Computer SimulationCorpus StriatumDopamineAnimalsDopamine Plasma Membrane Transport ProteinsModels, NeurologicalReceptors, Dopamine D1Receptors, Dopamine D2DopamineDopamine Plasma Membrane Transport ProteinsReceptors, Dopamine D1Receptors, Dopamine D2computational biologydopaminedopamine receptorsdopamine transportermouseneurosciencephasic versus tonic releasestriatumsystems biologythree-dimensional computational model

Identifiers

PMID41574574
PMCPMC12829992

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.