Evidence map›Paper›PMID 41574441›Full record

ArticleJournal of investigative medicine high impact case reports

When Textbook Meets Reality: A Rare Case of Boerhaave's Syndrome With Mackler's Triad.

Taiwo Ajani, Jose Loayza Pintado, Nayiri Derian, Andres Suarez, Ernesto Garza

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Article in Journal of investigative medicine high impact case reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

5 authors.

Taiwo AjaniUniversity of Texas Rio Grande Valley School of Medicine, Edinburg, TX, USA.
Jose Loayza PintadoUniversity of Texas Rio Grande Valley School of Medicine, Edinburg, TX, USA.ORCID 0009-0007-2241-3673
Nayiri DerianUniversity of Texas Rio Grande Valley School of Medicine, Edinburg, TX, USA.
Andres SuarezUniversity of Texas Rio Grande Valley School of Medicine, Edinburg, TX, USA.
Ernesto GarzaRio Grande Regional Hospital, McAllen, TX, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Boerhaave's syndrome is a rare and life-threatening form of spontaneous esophageal perforation, typically triggered by forceful vomiting and often misdiagnosed due to nonspecific clinical features. Although Mackler's triad (vomiting, chest pain, and subcutaneous emphysema) is classically associated with the condition, it is infrequently observed in full. We present the case of a 32-year-old man with a history of ulcerative colitis (UC) who presented to the emergency department with acute chest pain and repeated vomiting following dinner. He reported a sensation of food impaction and sought care 2 hours after symptom onset. Examination revealed subcutaneous emphysema and abdominal tenderness. Imaging with oral contrast-enhanced computed tomography revealed pneumomediastinum, pneumoperitoneum, and a distal esophageal perforation, confirming Boerhaave's syndrome. He underwent robotic-assisted laparoscopic repair with anterior fundoplication, endoscopic stenting, and drainage. His postoperative course included thoracentesis, IV antibiotics, and a gradual reintroduction of diet. A mild UC flare was managed with mesalamine. He was discharged in stable condition on postoperative day 9 and had full radiologic recovery at 3 months. This case stands out for its complete presentation of Mackler's triad, a rare occurrence that facilitated early diagnosis. The patient's young age and concurrent UC added clinical complexity. Prompt imaging and early minimally invasive surgical management, combined with coordinated multidisciplinary care, were key to a favorable outcome. This case underscores the importance of considering Boerhaave's syndrome in atypical presentations and acting swiftly when classical signs do appear.

Indexed as

Chest PainEsophageal PerforationMediastinal DiseasesVomitingAdultColitis, UlcerativeEsophageal DiseasesFundoplicationHumansLaparoscopyMaleMediastinal EmphysemaPneumoperitoneumRupture, SpontaneousSpontaneous PerforationTomography, X-Ray ComputedBoerhaave syndromeesophageal perforationMackler’s triadulcerative colitis

Identifiers

PMID41574441
PMCPMC12833163

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.