Trial reportFrontiers in medicine2025
Study on the effective dose of alfentanil combined with ciprofol in inhibiting intraoperative body movement responses in patients undergoing breast lump resection.
Trial report in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The clinical observation of ciprofol versus propofol anesthesia in hysteroscopic electrosurgical resection of submucosal myomas.Frontiers in medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Alfentanil and ciprofol are used in combination for intravenous anesthesia, but the effective dose of alfentanil required to suppress movement during surgery when co-administered with ciprofol is not well-defined. This study aimed to determine the effective dose of alfentanil, combined with ciprofol, required to inhibit body movement responses in patients undergoing breast lumpectomy. Methods: Patients scheduled for elective breast lumpectomy uswere selected. Ciprofol was administered intravenously at anesthesia induction, and alfentanil was given using the sequential method with an initial dose of 10 μg/kg and a dose gradient of 1 μg/kg. The dosage of alfentanil, the incidence of intraoperative respiratory depression, hypotension requiring treatment, and bradycardia were recorded. Postoperative adverse reactions were assessed and recorded. Probit regression analysis was used to calculate the effective dose. Results: The median effective dose (ED₅₀) of alfentanil for inhibiting intraoperative body movement was calculated to be 13.396 μg/kg, with a corresponding 95% effective dose (ED Conclusion: The ED Clinical trial registration: http://www.chictr.org.cn, ChiCTR2500109829.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.