ArticleFrontiers in cellular and infection microbiology2025
Comprehensive insights into pathogen distribution, clinical features, and outcomes in pediatric severe pneumonia.
Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Development of a nomogram to predict acute liver injury in children withFrontiers in pediatrics · 2026Article
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17 authors.
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Abstract
Objective: Pediatric severe pneumonia is a life-threatening condition with high incidence and mortality rates. This study provides a comprehensive analysis of pathogen distribution, infection patterns, clinical manifestations, and prognosis associated with the disease. Methods: This study involved 227 children with severe pneumonia and a control group of 227 with non-severe pneumonia. Targeted next-generation sequencing (tNGS) was applied to identify respiratory pathogens. Results: The median age of children with severe pneumonia was 12 months, markedly younger than the median of 24 months in the non-severe group. The tNGS identified suspected pathogenic microorganisms in 99.12% of the severe pneumonia cases, with predominant pathogens including Human Respiratory Syncytial Virus (33.92%), Cytomegalovirus (33.04%), Conclusion: Children with severe pneumonia tend to be younger than those with non-severe pneumonia. While significant differences are observed in the distribution of pathogens, complications, clinical manifestations, and prognosis between the two groups, no significant differences are noted in the number of infecting microorganisms or infection patterns.
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