Evidence map›Paper›PMID 41574301›Full record

ArticleFrontiers in cellular and infection microbiology2025

Binding of IgA1 and surface-expressed collagen-binding protein of

Daiki Matsuoka, Kana Suehara, Shuhei Naka, Taro Misaki, Yasuyuki Nagasawa, Seigo Ito, Yuto Suehiro, Ryota Nomura, Kazuhiko Nakano, Michiyo Matsumoto-Nakano

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Raman signatures ofFrontiers in microbiology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Daiki Matsuoka *Department of Pediatric Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan.
Kana Suehara *Department of Pediatric Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan.
Shuhei Naka *Department of Pediatric Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan.
Taro MisakiDivision of Nephrology, Seirei Hamamatsu General Hospital, Hamamatsu, Shizuoka, Japan.
Yasuyuki NagasawaDepartment of General Internal Medicine, Hyogo Medical University, Nishinomiya, Hyogo, Japan.
Seigo ItoDepartment of Internal Medicine, Japan Self-Defense Force Iruma Hospital, Saitama, Japan.
Yuto SuehiroDepartment of Pediatric Dentistry, Graduate School of Dentistry, The University of Osaka, Suita, Osaka, Japan.
Ryota NomuraDepartment of Pediatric Dentistry, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Kazuhiko NakanoDepartment of Pediatric Dentistry, Graduate School of Dentistry, The University of Osaka, Suita, Osaka, Japan.
Michiyo Matsumoto-NakanoDepartment of Pediatric Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The present study was conducted to examine the interaction between collagen-binding protein (Cnm) of Methods: The binding of Cnm to human immunoglobulins was examined using an enzyme-linked immunosorbent assay. A nephritis-induced rat model was employed to confirm the localization of Cnm. Results: IgA1 showed significantly greater binding ability to Cnm than to other bacterial surface proteins, and Cnm showed significantly greater binding ability to IgA1 than to other immunoglobulins. In rats administered Cnm, IgA deposition was observed in the glomerular mesangial region. Furthermore, biotin-labeled Cnm was observed in the same region as IgA deposition in the Cnm group. Conclusions: Taken together, it is considered that following invasion into the bloodstream, Cnm binds to and forms a complex with IgA1, leading to deposition of IgA1 in renal glomeruli.

Indexed as

Adhesins, BacterialCarrier ProteinsGlomerulonephritis, IGAImmunoglobulin AStreptococcus mutansAnimalsDisease Models, AnimalEnzyme-Linked Immunosorbent AssayHumansProtein BindingRatsAdhesins, BacterialCarrier ProteinsCnm protein, Streptococcus mutansImmunoglobulin Abacterial surface proteinscollagen-binding proteinhuman immunoglobulinsIgA nephropathyStreptococcus mutans

Identifiers

PMID41574301
PMCPMC12819641

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.