Evidence map›Paper›PMID 41574295›Full record

ArticleFrontiers in cellular and infection microbiology2025

OxyR contributes to the oxidative stress capacity and virulence of hypervirulent

Ruxia Zhang, Yu Zheng, Chao Ding, Jiayu Wu, Wanqiu Zhu, Xiaojue Zhu, Guoxin Xu, Long Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Characterization and pathogenic mechanisms of aFrontiers in microbiology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ruxia Zhang *Department of Clinical Laboratory, The First People's Hospital of Zhangjiagang City, Zhangjiagang Hospital Affiliated to Soochow University, Zhangjiagang, Jiangsu, China.
Yu Zheng *Department of Clinical Laboratory, The First People's Hospital of Zhangjiagang City, Zhangjiagang Hospital Affiliated to Soochow University, Zhangjiagang, Jiangsu, China.
Chao DingDepartment of Clinical Laboratory, The First People's Hospital of Zhangjiagang City, Zhangjiagang Hospital Affiliated to Soochow University, Zhangjiagang, Jiangsu, China.
Jiayu WuDepartment of Clinical Laboratory, The First People's Hospital of Zhangjiagang City, Zhangjiagang Hospital Affiliated to Soochow University, Zhangjiagang, Jiangsu, China.
Wanqiu ZhuDepartment of Clinical Laboratory, The First People's Hospital of Zhangjiagang City, Zhangjiagang Hospital Affiliated to Soochow University, Zhangjiagang, Jiangsu, China.
Xiaojue ZhuDepartment of Clinical Laboratory, The First People's Hospital of Zhangjiagang City, Zhangjiagang Hospital Affiliated to Soochow University, Zhangjiagang, Jiangsu, China.
Guoxin XuDepartment of Clinical Laboratory, The First People's Hospital of Zhangjiagang City, Zhangjiagang Hospital Affiliated to Soochow University, Zhangjiagang, Jiangsu, China.
Long ChenDepartment of Clinical Laboratory, The First People's Hospital of Zhangjiagang City, Zhangjiagang Hospital Affiliated to Soochow University, Zhangjiagang, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Hypervirulent Methods: In this study, VK055_RS16305 was first identified as an OxyR homologue in Results: Deletion of Discussion: Together, these findings demonstrate that OxyR is a key regulator of oxidative stress defense, biofilm formation, and systemic virulence in hvKP, providing new insight into OxyR-mediated pathogenic mechanisms in

Indexed as

Bacterial ProteinsKlebsiella InfectionsKlebsiella pneumoniaeOxidative StressRepressor ProteinsAmino Acid SequenceAnimalsAntioxidantsBiofilmsDisease Models, AnimalGene DeletionGene Expression Regulation, BacterialHydrogen PeroxideMaleMiceMice, Inbred C57BLAntioxidantsBacterial ProteinsHydrogen PeroxideRepressor Proteinsgene regulationhypervirulent Klebsiella pneumoniaeoxidative stressOxyRvirulence

Identifiers

PMID41574295
PMCPMC12819678

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.